ID A0A0B5HJ71_ARCG5 Unreviewed; 807 AA.
AC A0A0B5HJ71;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=QT03_C0001G0756 {ECO:0000313|EMBL:AJF60251.1};
OS Archaeon GW2011_AR10.
OC Archaea.
OX NCBI_TaxID=1579370 {ECO:0000313|EMBL:AJF60251.1, ECO:0000313|Proteomes:UP000031777};
RN [1] {ECO:0000313|Proteomes:UP000031777}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=25702576; DOI=10.1016/j.cub.2015.01.014;
RA Castelle C.J., Wrighton K.C., Thomas B.C., Hug L.A., Brown C.T.,
RA Wilkins M.J., Frischkorn K.R., Tringe S.G., Singh A., Markillie L.M.,
RA Taylor R.C., Williams K.H., Banfield J.F.;
RT "Genomic expansion of domain archaea highlights roles for organisms from
RT new phyla in anaerobic carbon cycling.";
RL Curr. Biol. 25:690-701(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; CP010424; AJF60251.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B5HJ71; -.
DR STRING; 1579370.QT03_C0001G0756; -.
DR KEGG; agw:QT03_C0001G0756; -.
DR HOGENOM; CLU_000203_6_0_2; -.
DR Proteomes; UP000031777; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00592; pol2; 1.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 78..294
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 384..786
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 807 AA; 92533 MW; 476C510446EBA80E CRC64;
MAKAVKKGTL LDVSYFLDDE KGIALNLFVK TQKGIEEFSE KKFKPYFYVV TDDAKKRLRE
LEKKEFGEEK IKPMKVEEVK KSNEENVLKL SFKNTHELIT ARESIEEMQG VKEKREYDIP
FAKRFLIDQS IEPMNGLELE VNEKNEVQKL RVYNTKKDLL DELSVACFDI ETYSPGRFSD
PSRDPIVSIA LSSGGKEKAF VWRQKPEKEK ADFFETEKEM LEAFLNEMAK SKPDIIVTYN
GDMFDFPYIK ERARVLKVDL KKGFGSEPDV RRKGLQNAVK LKGIQHVDAY QIVRLMTRFG
TVSLVKFDLE SVSFELFGKE KEKMTPEQIN KAWSTGTNID ALLQYNKEDA KTTLRIAETF
LPLFFEFSKL VHQTLFDSTR SSAGQLVEDL LIEKSFENNA LIPNKPQEGV VTQRLLQSFK
GGYVKEPVAG LHENIAVLDF RSLHPSIMIS HNVSPETLKC EHASCRNGKN LSPDKDWFCE
KKRGFIPTII EEILNKRIEI KNEMKKFKEG TPEFESLKAR QHALKIVLNS HYGYLGYARS
RWYSRESARA VTAWSRHYIR ESIHKAEKAG FNPIYSDTDS LFIIVPKGKT EKDVNAFVKK
INSELPGAME LEFEGYYKRG IFVTKKEGGA AKKRYALVDF KDSLKIVGFE YVRRDWARIA
KETQKEVIEA VLKEGKPEKA VEIVKKIVER LKKGEVTKKE LIIMTQIRRP LNKYENIGPH
VAAAQKAVKR GKEVGVGSTI SFIITKSGKS ISDKAELEEF VKEGNYDADY YINHQVLPAI
IKILAELGYS EEDLIQGGKQ QSLSSFM
//
