ID A0A0B5HZH1_9ACTN Unreviewed; 715 AA.
AC A0A0B5HZH1;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Serine/threonine protein kinase {ECO:0000313|EMBL:AJF65786.1};
GN ORFNames=SVTN_16675 {ECO:0000313|EMBL:AJF65786.1};
OS Streptomyces vietnamensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=362257 {ECO:0000313|EMBL:AJF65786.1, ECO:0000313|Proteomes:UP000031774};
RN [1] {ECO:0000313|EMBL:AJF65786.1, ECO:0000313|Proteomes:UP000031774}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GIMV4.0001 {ECO:0000313|Proteomes:UP000031774};
RA Deng M.R., Guo J., Ma L.Y., Feng G.D., Mo C.Y., Zhu H.H.;
RT "Complete genome sequence of Streptomyces vietnamensis strain GIMV4.0001, a
RT genetic manipulable producer of the benzoisochromanequinone antibiotic
RT granaticin.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr
CC protein kinase family. NIMA subfamily. {ECO:0000256|ARBA:ARBA00010886}.
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DR EMBL; CP010407; AJF65786.1; -; Genomic_DNA.
DR RefSeq; WP_041129809.1; NZ_CP010407.1.
DR AlphaFoldDB; A0A0B5HZH1; -.
DR STRING; 362257.SVTN_16675; -.
DR KEGG; svt:SVTN_16675; -.
DR HOGENOM; CLU_000288_135_1_11; -.
DR Proteomes; UP000031774; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR43671:SF13; LD04361P; 1.
DR PANTHER; PTHR43671; SERINE/THREONINE-PROTEIN KINASE NEK; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF13360; PQQ_2; 2.
DR SMART; SM00564; PQQ; 3.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:AJF65786.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000031774};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:AJF65786.1};
KW Transferase {ECO:0000313|EMBL:AJF65786.1}.
FT DOMAIN 22..282
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 288..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 715 AA; 75267 MW; 9F8FCFF6DADC467A CRC64;
MPPLRSTGAD RDAEGPEYAG EYRLQACLGA GGMGVVHLAT SPSGLRLAVK VVHGQYAEDP
EFRARFRQEV AAARRVSGAF TAPVVDADPD AVRPWMATLY VPGPTLADQV KRNGPLSPAE
LRRLTAGLAE ALRDIHRAGV VHRDLKPSNV LLTDTGPKVI DFGISRPVDS DLHTETGKLI
GSPPFMAPEQ FQRPREVGPA ADVFALGSVL VHAATGHGPF DSDSPYIVAY QVVHDEPDLT
GVPADLTPLV ARCLAKEPAE RPTPGEIMTA LLPPSYEAAA FIPSQRRAPV LPTPAPRSPG
SWDADTPVRV TTEQPRRRRP PRWPVTATAL LVLAGVGAFA AVQFSGDGAH TRDPHKAPVA
KAFAGWQTPL QKDGDTVAPA CGYIADALFC SGRGIAIARV DPGAGRVLWS QPAADSENFS
APAPMSGGLI GVSSADRGLR TYETDGNPGW YMKGAEHDSN VRFADETVLF AGGSGRLKAV
AAATGEQRWS HSLQGHSEPR FGPYDPVSDL LPVFEASSGA SGRAHTLISA LRPLSGEIAW
QKRLDGDLVP VGTGADGVLV LRSANRDSRT DAVVLYDPAK RSARRIPVPS LMDEPKVAVR
GTTVYLLTPT GQLIALDTAS PGGRVLWTLE TAAGTVSVPV VGPGDRLYFS ASDGRLLAVD
TARGALLGQT GPRLRDGRLG YATTIPAPVV AGDRVFGTAP DGSVFAVDAR DPAAW
//
