ID A0A0B5I510_9ACTN Unreviewed; 657 AA.
AC A0A0B5I510;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Acetoacetyl-CoA synthetase {ECO:0000313|EMBL:AJF69180.1};
DE EC=6.2.1.16 {ECO:0000313|EMBL:AJF69180.1};
GN ORFNames=SVTN_37815 {ECO:0000313|EMBL:AJF69180.1};
OS Streptomyces vietnamensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=362257 {ECO:0000313|EMBL:AJF69180.1, ECO:0000313|Proteomes:UP000031774};
RN [1] {ECO:0000313|EMBL:AJF69180.1, ECO:0000313|Proteomes:UP000031774}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GIMV4.0001 {ECO:0000313|Proteomes:UP000031774};
RA Deng M.R., Guo J., Ma L.Y., Feng G.D., Mo C.Y., Zhu H.H.;
RT "Complete genome sequence of Streptomyces vietnamensis strain GIMV4.0001, a
RT genetic manipulable producer of the benzoisochromanequinone antibiotic
RT granaticin.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP010407; AJF69180.1; -; Genomic_DNA.
DR RefSeq; WP_041133099.1; NZ_CP010407.1.
DR AlphaFoldDB; A0A0B5I510; -.
DR STRING; 362257.SVTN_37815; -.
DR KEGG; svt:SVTN_37815; -.
DR HOGENOM; CLU_000022_3_3_11; -.
DR Proteomes; UP000031774; Chromosome.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AJF69180.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000031774}.
FT DOMAIN 36..92
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 98..470
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 537..612
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 657 AA; 71008 MW; FD23666266BB8BF1 CRC64;
MTRPYPEPFT TPDPQAVADS RITDFARHAG LDGTDYAALH HWSVTDLEGF WGAVWDYFDI
DADTPYEQVL AEERMPGARW FPGATLNYTH HALRKLTDDT VAIIALDETG SSHEVTGGRL
RAQVASVAAT LRDLGVGKGD RVVGYLPNTP HAIVAFLAAA SLGAVWSVCG QDYAPKAAAD
RFAQLEPTVL IAADGYLFNG TTHDRREATL ELAGELPTLK AALLVDHVGL PWPTHTYPSL
VMQWEDASTR TEELTCTPVP FDHPLWVVFS SGTTGLPKGI VHGHGGVLLE HLKTLGLHSD
LGPGDRLLWY TTTHWMMWNL VASTLLTGAT TCTYDGSPAP FAQLDVLWEL AARHRVTVFG
TSPQYLLGMA KYGIDPSAHD LSSIRVVGCT GSALPASAYP WVRQHVGDHV LLASTSGGTD
VVSGFAGSAP NTPVWAGELS APHLGVALAA YDAEGFPVVD QVGELVVTRP MPSMPLCFWN
DPDGTRYRDA YFSSYPGVWR HGDWITVTGH GSVIVHGRSD STLNRNGVRL GSADIHDVVE
RLPEITEALV IGAEEPDGGY WMPLFVVLAA DATLDEPLRE KIKEAIRTGA SPRHVPDEIL
EVPGIPHTRT GKKLEVPVKR LLQGAPVEQV VNPAAVDAPD LIDHFARLGA ERRGRSL
//
