ID A0A0B5I7T6_9ACTN Unreviewed; 521 AA.
AC A0A0B5I7T6;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030904};
GN ORFNames=SVTN_21335 {ECO:0000313|EMBL:AJF66542.1};
OS Streptomyces vietnamensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=362257 {ECO:0000313|EMBL:AJF66542.1, ECO:0000313|Proteomes:UP000031774};
RN [1] {ECO:0000313|EMBL:AJF66542.1, ECO:0000313|Proteomes:UP000031774}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GIMV4.0001 {ECO:0000313|Proteomes:UP000031774};
RA Deng M.R., Guo J., Ma L.Y., Feng G.D., Mo C.Y., Zhu H.H.;
RT "Complete genome sequence of Streptomyces vietnamensis strain GIMV4.0001, a
RT genetic manipulable producer of the benzoisochromanequinone antibiotic
RT granaticin.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-
CC methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667,
CC Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530,
CC ChEBI:CHEBI:456215; EC=6.1.1.10;
CC Evidence={ECO:0000256|ARBA:ARBA00001234};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|RuleBase:RU363039}.
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DR EMBL; CP010407; AJF66542.1; -; Genomic_DNA.
DR RefSeq; WP_041130542.1; NZ_CP010407.1.
DR AlphaFoldDB; A0A0B5I7T6; -.
DR STRING; 362257.SVTN_21335; -.
DR KEGG; svt:SVTN_21335; -.
DR HOGENOM; CLU_009710_10_1_11; -.
DR Proteomes; UP000031774; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 2.20.28.20; Methionyl-tRNA synthetase, Zn-domain; 1.
DR InterPro; IPR023458; Met-tRNA_ligase_1.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR029038; MetRS_Zn.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR45765; METHIONINE--TRNA LIGASE; 1.
DR PANTHER; PTHR45765:SF1; METHIONINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039};
KW Reference proteome {ECO:0000313|Proteomes:UP000031774}.
FT DOMAIN 6..249
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
SQ SEQUENCE 521 AA; 57124 MW; 13309843A9234B65 CRC64;
MSTPVWITAT PPATHGELHI GHLAGPYVAA DVLTRFLRAD GEAVRFTTGT ADHASSVEVR
ALRHHRKPEE VAEGYRAAIT ADWLRSGVEF DHIVRPRRDK GYGRWVQDLF AKLYAQGVIA
PRTRLLPYCE PCDRWLHGAH ATGTCPHCGA ASDGGMCHEC ARPNDGGDLI SARCALCDTP
AVARRCRRLY VPLEPFRDTL ADYWATAGLP PRLAALCESL VEDGLPDIAV GHPGEWGLAV
PVEGFPEHRI DGCFEAAAMH LFGYDVKGPL PRRAIHFCGF GHAFCHAVLL PVLLLAQDVK
LPQDFNVNES YVIEEGVQEG NVWALDLLTE YGSDTLRRHV LQARPLGRRT VFQRERLAAA
RHELDENWNS WLSRLFSAVR EECGGLAPQA LPGGTGWEVL ERRLHRGVDD LREAYGPDAF
DPRRAVAVLD EMVRSAADFG HVNAHERCRP STSCRHLPAL AAQLAVASAL AAWSRPVMPE
GADRLASALR VEPGRPVDWH ALTGPLPGTR LAPPSGPVFG F
//
