ID A0A0B5IJJ8_9ACTN Unreviewed; 446 AA.
AC A0A0B5IJJ8;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=SVTN_17105 {ECO:0000313|EMBL:AJF69808.1};
OS Streptomyces vietnamensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=362257 {ECO:0000313|EMBL:AJF69808.1, ECO:0000313|Proteomes:UP000031774};
RN [1] {ECO:0000313|EMBL:AJF69808.1, ECO:0000313|Proteomes:UP000031774}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GIMV4.0001 {ECO:0000313|Proteomes:UP000031774};
RA Deng M.R., Guo J., Ma L.Y., Feng G.D., Mo C.Y., Zhu H.H.;
RT "Complete genome sequence of Streptomyces vietnamensis strain GIMV4.0001, a
RT genetic manipulable producer of the benzoisochromanequinone antibiotic
RT granaticin.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP010407; AJF69808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B5IJJ8; -.
DR STRING; 362257.SVTN_17105; -.
DR KEGG; svt:SVTN_17105; -.
DR HOGENOM; CLU_020931_2_0_11; -.
DR Proteomes; UP000031774; Chromosome.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000313|EMBL:AJF69808.1};
KW Oxidoreductase {ECO:0000313|EMBL:AJF69808.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031774}.
SQ SEQUENCE 446 AA; 49108 MW; 572F1FFBCEA44502 CRC64;
MNETVNETTP VYDVVGVGFG PANLALAIAI EEYNEQAAPA ERLTAVFLEK QPNFGWHRGM
LLPDATMQVS FLKDLATMRN PCSRFGFVPY LHDRGRLVDF INHKMLFPTR EEFHDYLQWA
ADGVDHMVRY GLEVTAIRPA GAAGPVVEVD VAAVGEAEAV TYRARNLVIG TGLVPRLPEG
VESSERLWHS SEFLHRLAAL PAAAPRRFVV AGAGQSAAEI ADHLHRTYEG AEVVAVHTRY
GYSPADDSPY ANRIFDPEAV DLYHGAEPSV RRTLMDYHRN TNYGVVDMDL IEELYRRSYQ
EKVRGEQRLR ILGVTRLTEV EEGPDGVRVQ VRNLATGETE TMEADAVVYA TGYSEPDPGR
LLGALGAACA RDEDGRLRVR RDYRVETAPG MEAGIYLMGG TEHSHGITAN LLSMAAVRAG
EICDSLVAGR RGGRRSDRRK SVAVTG
//
