ID A0A0B7F5K4_THACB Unreviewed; 1071 AA.
AC A0A0B7F5K4;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Regulator of nonsense transcripts 1 homolog {ECO:0000313|EMBL:CEL51497.1};
GN ORFNames=RSOLAG1IB_00032 {ECO:0000313|EMBL:CEL51497.1};
OS Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14) (Lettuce bottom
OS rot fungus) (Rhizoctonia solani).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Ceratobasidiaceae; Rhizoctonia; Rhizoctonia solani AG-1.
OX NCBI_TaxID=1108050 {ECO:0000313|EMBL:CEL51497.1, ECO:0000313|Proteomes:UP000059188};
RN [1] {ECO:0000313|EMBL:CEL51497.1, ECO:0000313|Proteomes:UP000059188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rhizoctonia solani AG1-IB 7/3/14 {ECO:0000313|EMBL:CEL51497.1};
RA Wibberg Daniel;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; LN679100; CEL51497.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B7F5K4; -.
DR STRING; 1108050.A0A0B7F5K4; -.
DR Proteomes; UP000059188; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000059188};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 86..241
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 94..126
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 108..136
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 154..184
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
SQ SEQUENCE 1071 AA; 118711 MW; A8E68114295AE3FD CRC64;
MDTFDNFQSE YGGIGDDDTA SIISGYTQRT GAGFSKPTLN AADALDLDAL SIADDHVANR
RSDLANDFAG TLDDDFDANL EDNGIGFDLP EYACSYCGIH SPASVVKCLI CSKWFCNSRG
NTSASHIVNH LVRAKHKEVV LHAESPLGET TPECYNCGSK NAFMLGFIPA KSDTVVVLLC
RQPCAAISKD ISWNTALWAP LIEDRSFLSW LVTPPSEQEQ LRARQITYAQ INRLEDLWRE
NANATLEDLA KPGVDDEPQP ILQRYEDAYQ YQNIFGPLVK IEADYDKRLK ESQTQDDVVV
RWDQGLNQKR IAWFNFPKLE SGEVRLAVGD ELRLRYHGDS HHAWEGSGHV LKIPNNISDE
IGLELRRNDG VPVDCTHGFS VDFVWKSTSF DRMQLAMKTF AIDEKSVSGY IYHKLLGHDL
EPTILRTQMP KRFSAPGLPE LNHSQMYAVK SVLQKPISLI QGPPGTGKTV TSASIVYHLA
KMNPGQVLVC APSNVAVDQL TEKIHATGLK VVRLTAKSRE ALESSIAFLT LHRQVAAYTS
HTELQKLIQL KNELGELSQS DERKYKTLVR NVEREILAAA DVICCTCVGT GDPRLSKLKF
RTVLIDEATQ AAEPECMIPL VLGCKQVVLV GDHQQLGPVI MNKKAARAGL TQSLFERLVL
LGNRPIRLQV QYRMHPCLSE FPSNMFYEGT LQNGVTAPER LRKNVDFPWP VADTPMMFYQ
NLGQEEISSS GTSFLNRTEA SNVEKIATKF FKAGVVPAQI GVITPYEGQR SYIVNYMQYH
GTLKKDLYKD IEVASVDAFQ GREKDYIILS CVRSNEHQGI GFLNDPRRLN VALTRAKYGV
VILGNPKVLS KHPLWHYLLT HYKEKQCLVE GPLNNLQPSM IQFSKPRRAL NKSMEQFRRH
DFSDAEGTSG APVLNDTRRA SASAYDSNFY RTHDPLGYIP SDVQSLKSSA SGLPHFGTAA
SFGPSKQKAP AGQKRATYAS YASSIISQDV AGAPGGTDAS SVAGSQFEHN GSIVFSQSDR
IRRRNSLTSM AGTSDIGSMS AYDYKSQDSV IDADDSESQY AHSVQSGVTE F
//
