ID A0A0B7FFF6_THACB Unreviewed; 1203 AA.
AC A0A0B7FFF6;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ppk4 {ECO:0000313|EMBL:CEL54938.1};
GN ORFNames=RSOLAG1IB_07430 {ECO:0000313|EMBL:CEL54938.1};
OS Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14) (Lettuce bottom
OS rot fungus) (Rhizoctonia solani).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Ceratobasidiaceae; Rhizoctonia; Rhizoctonia solani AG-1.
OX NCBI_TaxID=1108050 {ECO:0000313|EMBL:CEL54938.1, ECO:0000313|Proteomes:UP000059188};
RN [1] {ECO:0000313|EMBL:CEL54938.1, ECO:0000313|Proteomes:UP000059188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rhizoctonia solani AG1-IB 7/3/14 {ECO:0000313|EMBL:CEL54938.1};
RA Wibberg Daniel;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; LN679118; CEL54938.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B7FFF6; -.
DR STRING; 1108050.A0A0B7FFF6; -.
DR Proteomes; UP000059188; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd10422; RNase_Ire1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF01011; PQQ; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 2.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CEL54938.1};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000059188};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CEL54938.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1203
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002113924"
FT DOMAIN 777..1066
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1069..1201
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 410..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..706
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1203 AA; 132160 MW; 2AA94DCF00B81366 CRC64;
MLPALIQLCV LAIVLCVAAE PFRRSSHASI QKFSKDLATA KRPSSSLPWG KGREKGPMIP
HSVPGPSTAG QDVRLLDIVL AASVDGRFHA LNRTTGELIW SMADDLAYVQ SPRDPNTEGV
PSMGSQTPLY NLVRSDHRSL IDSEQVDEEE ETYVVEPQTG EVFVLHPGDA PVERLGYSVP
QLAELSPFIP PGDDERVFHG TTSTSLITID LLTGRILGVY GEHCTWDDNG PSDESPIDVN
AMLDDLDGTQ ELPQKQRPIE VVVGRTDYHV SVYVKGRGVV QNLKFTKYGP NNIHRAIQAA
WNRSPDSTYF QPSPDGRLYS FAKGSILSYV PTYPLIVAIF DAVYLPTRRD PILLLQPIPR
LSDLSASRSA DMDLPEVTYI GRIDDSLFAL GHTTYPLVLF SHVGKKQLPR IDDGGKAPNS
SPPPDSDSST ERCYDLDCLT GTKWSESARR SGLNRLIGEE HVLYIDGSAG VEDAPEDYPS
HDIPQSKPDP PRTRKQPQTL APRPTRTTNS TSHARPAIED KTPEATPSPR SGIRGVAREW
LAAWASMGGV VLSTVMFGLG LGVRRGKLSV GPILLKVLGI RNNASSAEPG SKPVAEEEED
ETPPPVPPKP YSISKITQNP YLMTADSRPG AALKDTPATP PRRRIRPRVR GGVPASASVP
ALLTVNPAGQ LTTSKSAGDV TTEGDITEEP ESQVIEDKKE PENTETEIEG PVEEANTPGK
KRVRRGRRGK GRGKGASTGD ANKNGVETEG VLSEGSESFI RVEKAEKAPV VAKSSLAVSE
EVLGYGSHGT VVYKGKFQGR SVAVKRLLHD FVTLASREVA LLQESDDHPN VIRYYYEEHR
ENFLYIALEL CPCSLSDLIE RPQMFPDVVG SFDPKRALSQ VTAGLRHLHA LKIVHRDIKP
QNILVSARGA MLISDFGLCR KLDVDQTSFM PTAYGGAAAG TAGWRAPEIL RGEVNVDMAA
LDVSNGGIGS SSSSGSGNAT SGTRLTRSVD VFALGCLFFY VLSGGDHAFG DRFERDVNIL
RDEKRLGWLE RLGEEGFEAI GLIEKMLSPD PRKRPDTTKC LMHPFFWTPS RRLAFLQDAS
DRFEIMERDP REPGLVALET GAVEIIGNDW QRRLDKMFID NLGKFRKYDV TSVQDLLRAL
RNKKNHYQDL PDNVKRHLGP LPEGFLSYFT RRFPKLFSHV YSVVEGSSLQ VEPMFRPYFV
LEE
//
