ID A0A0B7FU61_THACB Unreviewed; 363 AA.
AC A0A0B7FU61;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Methylenetetrahydrofolate dehydrogenase (NAD+) {ECO:0000313|EMBL:CEL59712.1};
DE EC=1.5.1.15 {ECO:0000313|EMBL:CEL59712.1};
GN Name=MTD1 {ECO:0000313|EMBL:CEL59712.1};
GN ORFNames=RSOLAG1IB_03645 {ECO:0000313|EMBL:CEL59712.1};
OS Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14) (Lettuce bottom
OS rot fungus) (Rhizoctonia solani).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Ceratobasidiaceae; Rhizoctonia; Rhizoctonia solani AG-1.
OX NCBI_TaxID=1108050 {ECO:0000313|EMBL:CEL59712.1, ECO:0000313|Proteomes:UP000059188};
RN [1] {ECO:0000313|EMBL:CEL59712.1, ECO:0000313|Proteomes:UP000059188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rhizoctonia solani AG1-IB 7/3/14 {ECO:0000313|EMBL:CEL59712.1};
RA Wibberg Daniel;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN679103; CEL59712.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B7FU61; -.
DR STRING; 1108050.A0A0B7FU61; -.
DR Proteomes; UP000059188; Unassembled WGS sequence.
DR GO; GO:0004487; F:methylenetetrahydrofolate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR PANTHER; PTHR48099:SF3; METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:CEL59712.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000059188}.
FT DOMAIN 18..133
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00763"
FT DOMAIN 180..246
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF02882"
SQ SEQUENCE 363 AA; 39334 MW; 160C15178CF38A4E CRC64;
MAAPASAQLG IGKLVKADGI AGKFRSEIEQ SLSKPSSLAR KPRLLGILST SSAPSRSYAQ
FTKKTCEAIG IEFVLKEVGG AVEGGVDGEG AEEAIIEANE DRSVDGIMVY YPIFGGSQDH
YLQQVVSPFK DVEGLHVKFH YNLYHNIRFI RPQSLAGLPG SMDSPTVPTP AAEAPEGYVK
SIIPCTPLAI VKALEAIGVY NSILDYGDRA YGRTVTIINR SEVVGRPLAA LLSNDGARVF
SVDIDSIQEY TKRPVTNAGG NERLKRFNPR HVVHPCSLSL EQCLALSDVV VSAVPSATYK
VPTGWLKDGC ICVNVASEKN FESDVREKAS LYMPAVGKIT QMMLLRNLLR LCQYRELLEN
TAT
//