ID   A0A0B7H589_9FLAO        Unreviewed;       373 AA.
AC   A0A0B7H589;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) {ECO:0000256|ARBA:ARBA00038858};
DE            EC=5.1.3.14 {ECO:0000256|ARBA:ARBA00038858};
GN   Name=rffE {ECO:0000313|EMBL:CEN34776.1};
GN   ORFNames=CCYN2B_230013 {ECO:0000313|EMBL:CEN34776.1};
OS   Capnocytophaga cynodegmi.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Capnocytophaga.
OX   NCBI_TaxID=28189 {ECO:0000313|EMBL:CEN34776.1, ECO:0000313|Proteomes:UP000038055};
RN   [1] {ECO:0000313|Proteomes:UP000038055}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ccyn2B {ECO:0000313|Proteomes:UP000038055};
RA   MANFREDI Pablo;
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC         mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:68623; EC=5.1.3.14;
CC         Evidence={ECO:0000256|ARBA:ARBA00036080};
CC   -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC       {ECO:0000256|ARBA:ARBA00038209, ECO:0000256|RuleBase:RU003513}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CDOD01000016; CEN34776.1; -; Genomic_DNA.
DR   RefSeq; WP_041991655.1; NZ_CDOD01000016.1.
DR   AlphaFoldDB; A0A0B7H589; -.
DR   Proteomes; UP000038055; Unassembled WGS sequence.
DR   GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:UniProtKB-EC.
DR   CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR   InterPro; IPR029767; WecB-like.
DR   NCBIfam; TIGR00236; wecB; 1.
DR   PANTHER; PTHR43174; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR   PANTHER; PTHR43174:SF2; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR   Pfam; PF02350; Epimerase_2; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU003513};
KW   Reference proteome {ECO:0000313|Proteomes:UP000038055}.
FT   DOMAIN          23..369
FT                   /note="UDP-N-acetylglucosamine 2-epimerase"
FT                   /evidence="ECO:0000259|Pfam:PF02350"
SQ   SEQUENCE   373 AA;  42197 MW;  270049C8BEBA42F5 CRC64;
     MKKILLIFGT RPEAIKMAPL VRAFQKDNSF ETKVCVTAQH RQMLDQVLEF FAVVPNYDLD
     LMKPNQNLYT LTADIITGLK SVLEDFQPHY VFVHGDTTTT MAASIASFYA GARVCHIEAG
     LRTFNKYAPF PEEINRQVTG RIADYHFAPT PTSKQNLLKE HIAEDTILVT GNTVIDALLE
     SIERVEHIQD KEIEELKSIV DTSKKLILVT GHRRENHGSG FIEICEALKE IAINNPDVQI
     VYPVHLNPNV QKPVYQILSQ IENVHLIDPL SYPAFVWLMK YSYLIITDSG GVQEEAPSLG
     KPVLVMRDTT ERPEAIEAGT VILVGTDKKR ITKECELLLN NTEKYIQMSR LINPYGDGKA
     CERIIKFLKN KTE
//