ID A0A0B7I7L7_9FLAO Unreviewed; 270 AA.
AC A0A0B7I7L7;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=orotidine-5'-phosphate decarboxylase {ECO:0000256|ARBA:ARBA00012321};
DE EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
GN Name=pyrF {ECO:0000313|EMBL:CEN47685.1};
GN ORFNames=CCAND38_460019 {ECO:0000313|EMBL:CEN47685.1}, CCAND93_490012
GN {ECO:0000313|EMBL:CEN53596.1};
OS Capnocytophaga canis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Capnocytophaga.
OX NCBI_TaxID=1848903 {ECO:0000313|EMBL:CEN47685.1, ECO:0000313|Proteomes:UP000045051};
RN [1] {ECO:0000313|Proteomes:UP000038200, ECO:0000313|Proteomes:UP000045051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CcD38 {ECO:0000313|EMBL:CEN47685.1,
RC ECO:0000313|Proteomes:UP000045051}, and CcD93
RC {ECO:0000313|EMBL:CEN53596.1, ECO:0000313|Proteomes:UP000038200};
RA MANFREDI Pablo;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001419};
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
CC -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 2 subfamily.
CC {ECO:0000256|ARBA:ARBA00008847}.
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DR EMBL; CDOI01000158; CEN47685.1; -; Genomic_DNA.
DR EMBL; CDOL01000238; CEN53596.1; -; Genomic_DNA.
DR RefSeq; WP_042008480.1; NZ_CDOL01000238.1.
DR AlphaFoldDB; A0A0B7I7L7; -.
DR STRING; 1848903.CCAND38_460019; -.
DR OrthoDB; 9808470at2; -.
DR UniPathway; UPA00070; UER00120.
DR Proteomes; UP000038200; Unassembled WGS sequence.
DR Proteomes; UP000045051; Unassembled WGS sequence.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04725; OMP_decarboxylase_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR011995; OMPdecase_type-2.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR02127; pyrF_sub2; 1.
DR PANTHER; PTHR43375; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR PANTHER; PTHR43375:SF1; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:CEN47685.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000045051}.
FT DOMAIN 16..254
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 270 AA; 30207 MW; D08F87F7C6B3AF47 CRC64;
MTLQKLINQI RKKKSFLCVG LDVDLTKVPS HLLQTEDPIF EFNKAIIDAT HSFAVAYKPN
TAFYEAYGVK GWQSLAKTIA YINENHSDIF TIADAKRGDI GNTSAMYAKA FFNDLQFDSV
TVAPYMGKDS VEPFLAFEDK ITILLALTSN AGAFDFQTQM VNNEELYKKV LQTSLTWENS
QNLMYVVGAT KAEYLKEIRK IVPNHFLLVP GVGAQGGSLD EVCEYGLNAD NGLLINSSRG
IIYASNGTDF AEKAREEAQK LQQQMEKWVR
//
