ID   A0A0B7ITK1_9PROT        Unreviewed;       330 AA.
AC   A0A0B7ITK1;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=HpcH/HpaI aldolase {ECO:0000313|EMBL:CEN55578.1};
GN   ORFNames=BN1209_0533 {ECO:0000313|EMBL:CEN55578.1};
OS   Candidatus Methylopumilus turicensis.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylopumilus.
OX   NCBI_TaxID=1581680 {ECO:0000313|EMBL:CEN55578.1, ECO:0000313|Proteomes:UP000056322};
RN   [1] {ECO:0000313|Proteomes:UP000056322}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MMS-10A-171 {ECO:0000313|Proteomes:UP000056322};
RA   Salcher M.M.;
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR   EMBL; LN794158; CEN55578.1; -; Genomic_DNA.
DR   RefSeq; WP_045750827.1; NZ_LN794158.1.
DR   AlphaFoldDB; A0A0B7ITK1; -.
DR   STRING; 1581680.BN1209_0533; -.
DR   KEGG; mbac:BN1209_0533; -.
DR   HOGENOM; CLU_073837_0_0_4; -.
DR   Proteomes; UP000056322; Chromosome 1.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.140.960; -; 1.
DR   Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR   InterPro; IPR005000; Aldolase/citrate-lyase_domain.
DR   InterPro; IPR040186; Citramalyl-CoA_lyase.
DR   InterPro; IPR011206; Citrate_lyase_beta/mcl1/mcl2.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR   PANTHER; PTHR11105:SF0; CITRAMALYL-COA LYASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11105; CITRATE LYASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF03328; HpcH_HpaI; 1.
DR   PIRSF; PIRSF015582; Cit_lyase_B; 1.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
PE   4: Predicted;
KW   Magnesium {ECO:0000256|PIRSR:PIRSR015582-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR015582-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000056322}.
FT   DOMAIN          52..239
FT                   /note="HpcH/HpaI aldolase/citrate lyase"
FT                   /evidence="ECO:0000259|Pfam:PF03328"
FT   BINDING         87
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015582-1"
FT   BINDING         152
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015582-2"
FT   BINDING         152
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015582-1"
FT   BINDING         178
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015582-2"
SQ   SEQUENCE   330 AA;  36660 MW;  0F7AF7DF0C0FC4B2 CRC64;
     MNTLVHPNDA LFKGEKAFPV IPSCEHFAGS EKLILKALQI QDELGPIFDI TCDCEDGAAA
     GQEREHAEMI VRVQQSQANK HKMAGVRIHD YTHPAWRQDV DIFVEGIGNL VAYITIPKST
     NAAQVKEMIT YIQTKCKEHG IKREIPIHIL IETHGALHEV FEIAALPWIQ VLDFGLMDFV
     SGHHGAIPAS AMRSPGQFEH RLLARAKSEV VAAALMHGIV PAHNVSLDLK NTVATNSDAS
     RARQEFGFLR MWSIYPTQIQ AIVDAMKPNL DEVQDAADIL IAAQKAEWGP IQHAGELHDR
     ATYRYYWEVL QKAKVSGISI PAEAEHAFFA
//