ID A0A0B7NHJ0_9FUNG Unreviewed; 2501 AA.
AC A0A0B7NHJ0;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 22-FEB-2023, entry version 37.
DE RecName: Full=MPN domain-containing protein {ECO:0000259|PROSITE:PS50249};
GN Name=PARPA_09041.1 scaffold 35481 {ECO:0000313|EMBL:CEP14852.1};
OS Parasitella parasitica.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Parasitella.
OX NCBI_TaxID=35722 {ECO:0000313|EMBL:CEP14852.1, ECO:0000313|Proteomes:UP000054107};
RN [1] {ECO:0000313|EMBL:CEP14852.1, ECO:0000313|Proteomes:UP000054107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 412.66 {ECO:0000313|EMBL:CEP14852.1,
RC ECO:0000313|Proteomes:UP000054107};
RA Ellenberger Sabrina;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN731759; CEP14852.1; -; Genomic_DNA.
DR STRING; 35722.A0A0B7NHJ0; -.
DR OrthoDB; 246127at2759; -.
DR Proteomes; UP000054107; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0030623; F:U5 snRNA binding; IEA:InterPro.
DR GO; GO:0017070; F:U6 snRNA binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd08056; MPN_PRP8; 1.
DR CDD; cd13838; RNase_H_like_Prp8_IV; 1.
DR Gene3D; 1.20.80.40; -; 1.
DR Gene3D; 3.30.420.230; -; 1.
DR Gene3D; 3.90.1570.40; -; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR012591; PRO8NT.
DR InterPro; IPR012592; PROCN.
DR InterPro; IPR012984; PROCT.
DR InterPro; IPR027652; PRP8.
DR InterPro; IPR021983; PRP8_domainIV.
DR InterPro; IPR043173; Prp8_domainIV_fingers.
DR InterPro; IPR043172; Prp8_domainIV_palm.
DR InterPro; IPR019581; Prp8_U5-snRNA-bd.
DR InterPro; IPR042516; Prp8_U5-snRNA-bd_sf.
DR InterPro; IPR019580; Prp8_U6-snRNA-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR019582; RRM_spliceosomal_PrP8.
DR PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF08082; PRO8NT; 1.
DR Pfam; PF08083; PROCN; 1.
DR Pfam; PF08084; PROCT; 1.
DR Pfam; PF12134; PRP8_domainIV; 1.
DR Pfam; PF10598; RRM_4; 1.
DR Pfam; PF10597; U5_2-snRNA_bdg; 1.
DR Pfam; PF10596; U6-snRNA_bdg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50249; MPN; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054107};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 2271..2402
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
SQ SEQUENCE 2501 AA; 291272 MW; 5F2493E92B337E6D CRC64;
MLRIQQVQQR AGHQQAAGAQ QLRVETRYLS ERCITIDLPS LSCNTLLIAI ITDEHKIRFH
LKPAYIIPTI SNVIPPFSRK QIFKDIPTVI QERKERNKTV NLPPPPILPV RRSKSVMSLP
RFCKMQTSYE QPSPIDVVEQ LFAVRVAEPI MANNDSGVPI PVGGAPSAYS NQYDQYAYES
NPQTEKSQQD KLKEKARKWQ QLQNKRYGEK RKFGFIEHEK ADMPPEHLRK IIKDHGDMTA
KKFRHDKRIY LGALKYVPHA VLKLLENMPM PWEQVREVNV LYHITGAITF VNEIPWVIEP
VYIAQWGSQW IMMRREKRDR RHFKRMRFPP FDDEEPPLDY GDNIMDVEPL EAIQMELDEE
EDAAIYEWFY DNKPLMDTKF VNGSTYRKWR LDLPIMSTLY RVAHQLLSDL NDKNYFYLFD
LNSFFTAKAL SMAIPGGPKF EPLYRDMDTA DDDWNEFNDI NKIIIRQPVR TEYKIAFPFL
YNSLPRSVKV SWYHYPTVVF IRTEDPDLPA FYFDPIINPI SSRNVDAASK EHEDEIFGDN
DEDTEFTLPS NVVPFLDDSK LYTDNTANAI SLYWAPHPFD KRSGRTRRAQ DVPLVKSWYL
EHCPAGQPVK VRVSYQKLLK CYVLNALHQR PPKALNKKYL FRSLKSTKFF QTTQIDWVEA
GLQVCRQGYN MLNLLIHRKN LNYLHLDYNF NLKPVKTLTT KERKKSRFGN AFHLCREILR
LTKLIVDSHV QYRLGNVDAF QLADGLQYIF SHVGQLTGMY RYKYRLMRQI RMCKDLKHLI
YYRFNTGPVG KGPGVGIWAP GWRVWLFFMR GIVPLLERWL GNLLARQFEG RHSKGIAKTV
TKQRVDSHYD LELRAAVLHD IMDAMPEGIK GNKSRTILQH LSEAWRAWKA NIPWKVPGMP
APIENMILRY IKAKADWWTS VAHYNRERIR RGATVDKTIC RKNLGRLTRL WLKAEQERQH
NYLKDGPYIT AEEAVAIYTS TVHWLESRKF SPIPFPPLSY KHDTKLLILA LERLREAYSV
QGRLNQSQRE ELGLIEQAYD NPHEALSRIK RLLLTQRAFK EVGIEFMDLY SHLIPVYDIE
PLEKITDAYL DQYLWYEADK RHLFPAWIKP SDSEPPPLLV YKWCQGINNL TDVWDTAEGQ
CNVMMETSFS RVYEKIDLTL LGRLLRLILD HNLADYATAK NNVVLNYKDM NHVNAFGLIR
GLQFASFIFQ YYGLVLDLLV LGLHRASEMA GPPQLPNDFL QYRDVETETR HPIRLYSRYI
DRIHIFFRFT ADEARDLIQR YLTEHPDPNF ENIVGYNNKK CWPRDCRMRL MKHDVNLGRA
AFWDIKNRLP RSLTTIEWEN SFVSVYSKDN PNLLFSMSGF EIRILPKIRS MNEEFTLKDG
VWNLVNEQTK ERTAQAYLRV DQESMDKFHN RIRQILMASG STTFSKIANK WNTALIGLMT
YYREAVVHTR ELLDLLVKCE NKIQTRVKIG LNSKMPSRFP PVVFMTPKEL GGLGMLSMGH
VLIPQSDLRW SKQTDTGITH FRSGMSHDED TLIPNLYRYI QSWESEFVDS KRVWAEYALK
RQEANAQNRR LTLEDLEDSW DRGIPRINTL FQKDRHTLAY DKGWRVRTDF KQYQVLKNNP
FWWTHQRHDG KLWNLNNYRT DMIQALGGVE GILEHTLFKG TGHTSWEGLF WEKSSGFEQS
MASKKLTNAQ RSGLNQIPNR RFTLWWSPTI NRANVYVGFQ VQLDLTGIFM HGKIPTLKIS
LIQIFRAHLW QKIHEALTMD FAQVFDRELE ALQIETVQKE TIHPRKSYKM NSSASDILLF
AAYKWPVSRP SLLNDPKDVM EGPTTTKYWL DIQLRWGDFD SHDIERYTRA KFLDYTTDNM
SIYPSPTGLM VGVDLAYNMY SAYGNWIPGM KPLVQQAMGK IMKANPALYV LRERIRKALQ
LYSSEPTEPY LSSTNYGELF SNQIIWFVDD TNVYRVTIHK TFEGNLTTKP INGAIFIFNP
RTGQLFLKII HTSVWAGQKR LGQLAKWKTA EEVAALIRSL PVEEQPKQII VTRKGMLDPL
EVHLLDFPNI VIKGSELQLP FQACLKVEKF GDLILRATEP QMVLFNLYDD WLKTFSSYTA
FSRLVLILRA LHVNTDKTKM ILRPDRSTIT EPHHIWPTLS DEEWAKVEVQ LKDLILADYG
KKNNVNVASL TQSEIRDIIL GMEIQAPSLQ RQQIAEIEKQ TKEQSQLTAV TTKTHNIHGD
EMVVTTTSNY EQATFSSKTE WRIRAISATN LYLRTNHIYV NSDDIKEDTY TYVMPKNVLK
RFITISDLRT QIAGFMYGVS PPDAPNVKEI RCVVIPPQWG THQTVHLPNT LPEHEYLSDL
EPLGWIHTQP QELMNVSPQD VTTHAKLLAN NKTWDGEKTV VLTCSFTPGS CSLTAYKLSP
AGFEWGKTNV DPGSQPQGYL PTHGEKVQVL LSDRFLGYFM VPSDIWNYNF MGAQFSANIN
YRLVLDVPKE FYHESHRAAH FMNFSSEVEA SAEADIEDVF A
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