ID A0A0B7NHX6_9FUNG Unreviewed; 3972 AA.
AC A0A0B7NHX6;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN Name=PARPA_09345.1 scaffold 36060 {ECO:0000313|EMBL:CEP15144.1};
OS Parasitella parasitica.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Parasitella.
OX NCBI_TaxID=35722 {ECO:0000313|EMBL:CEP15144.1, ECO:0000313|Proteomes:UP000054107};
RN [1] {ECO:0000313|EMBL:CEP15144.1, ECO:0000313|Proteomes:UP000054107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 412.66 {ECO:0000313|EMBL:CEP15144.1,
RC ECO:0000313|Proteomes:UP000054107};
RA Ellenberger Sabrina;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN731879; CEP15144.1; -; Genomic_DNA.
DR STRING; 35722.A0A0B7NHX6; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000054107; Unassembled WGS sequence.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 4.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000054107}.
FT DOMAIN 2691..3259
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3610..3939
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3940..3972
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 478..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2095..2130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3279..3434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3725..3759
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 488..509
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3279..3318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3319..3391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3398..3425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3972 AA; 447922 MW; 2A9535522C4CEF39 CRC64;
MTTLQVYAHR LGDSNLAPGL KVTIANDLRD QVEVFQTLEY PRFLATLIPV FVDILQNGNP
VFQSNVPEQK LRNIILEIIY RLPQTDALKD YAVDLCKMLM HLLKVENEDN AVVCVKIIID
LHRTFRQLLE DQVQPFLDIV QDIFKNMEQT VKDVFDAPST PIGSATPGTN PLLAASPRPN
SPAAAAAAAA AAAEVTESPS KPLPKSMFSF KVLTECPIIV VLLFQSHRRY ATDNIMKFVP
LIFQTLGLQA KPQAEAANAA QARGEVFVGV SPEIRNRSVY NDFIVAQVKT MSFLAYILRS
YTQFLRPFQS QIPEYVLRLL RECPPESSGT RKELLVATRH ILSTDFRSSF VPKIELLLNE
KVLIGTGVTS HDTLRPLAYS MLADLVHHIR SELTPSQLYQ TVYIYSRNLH DATLAPSIQT
MCGKLLLNLI DCIIKIPNKK EGRDLLMRIL DAFASKFAAL NIQFKSCLKQ HMKKTSTADA
PFSSSPSSPS SPSSPSPSSV PPPPPLPQKE EQDFDFDKAR SIHTASFSFD PQLDGIKDGR
FLFKNLAIGL KPLFIGLRHC NPTPPPAQAA ADNANTLMYS QFARGFSEQD VHVFLRLFRE
GLVCFEYYNI DHYGPDGSPL TATGANKDQD TSDVNKNSSS TTAAATTTTT NNNGGDDVHN
GIGCNELSLK ISAQVAPEKE ILDMFATVFT LLDPAVFQEI FVSQMGFFFD RMLVNTALVH
IAQHLIVNEI ASPGFAAILF RFLMDRIEDL GDQDVHYAAV MLHLYRLAFM AVNLFPDTNE
AILQPYLGHL VTSCFKLSAK AQEPANYFLL LRLLFKSIGG GRFELLYKEV SPLLQVLLES
LNSLLTLAHR TEMRNLFVEL CLAVPVRLST LLPYLPYLMR PLVIALQADQ HELVSQGLRT
MELCNDNLNP EFLDQIMAPV MDELMSALWS HLRPLPYSQQ HSHVAMRILG KLGGRNRRML
NRPAELDCHE RVESGVSLEI LFDANSTPHT LPLDKCLQVA CNTLDMRDAD PFYKKHAYEF
LKANIVMMLE LDQGPDSLAQ SLYQRVKEHL LQPEESAPAI EKSDTSQQEK AATDMDVDTK
EGAESTVVGD ALAGSGLKPK RLAGNGYIKY LSKRVGQEDS LRTMLVAILK ASTLAELADD
AWPLFQHICR HFMLLHIGEA IEAKETGNKP LSDMLDERLS VQSLNTTILV DAIVKVISSQ
DAKLRARAEK SVQLCFDTAV KVLGGSKDYV WQLPIFRVFA SQFGSCCYKQ EWFNKRGGCL
GISFISSQLD MGTKWMREHE LDFIRSLLFV LKDASPEMAN VNTAEATQTL AHVLKVCNRP
EDDESPEAQQ KFQNLIALLL SELSNSNSAV RETIQSSFQL LADLTGNEVT ELLAPVRERL
VAPIFAKPLR ALPFAMQIGH IDAITYCLTL RPPFLDFNDE LIRLLHEALA LADAEDQALV
SRSSQYKNAT SLMNLRIVCI KLLSAAMACS DFSNQRQTHT RARIIQVFFK SLYSKAPEVV
EAAHRGLKQV LAQQHKLPKE LLQQGLRPIL TTLSNHKTLS VAGLEGLARL LELLTNYFKV
EIGKKLLDHL RQWADPKMLQ EAAGKNLSEN HQIKIIVAIL NIFHLLPSAA HIFLDDLVTV
VLEMEAHLRR SVSSPFRPNL IKYLNRYPAE TVAYFYDRLD QPRHSRLFVD ILATENAEQL
RDQVAKSPKV LIEKTFQVAD TAATMTTLHY QGVLIVREIV ANNPKWLLGQ QELMDSLLSL
WRSPTRFDTM KKNDEQGLET THESMYMSQI FIAYLRLDPP DYIDVLFEVA ALFAQESVMD
LSYLREFFLN DVALNYSPQQ KRLVVERFLQ QHYADTSVSP YLRMMMLRHV VNPALLVAIA
QNDSSCAQVL DPKLMEQLHG KIWSQTFSFD AGEQDQYAED SLRIELLQLT AMIIQYAPQL
MTDMRKDVIK FGWHYLRLED ATCKQAAYVL IARFIAAFET PSKIVIQIYA ALLRAHLSEA
RTLVKQGLDI ISPVLPKRVP LAANERVPTW IRLTRRVIVE DTHSISQMVN VYQLLVRQPT
LFYDYREHFL PQIINALPKL GLLQNATPEN KLLTVELAEL VLAWEEMRIK QTQDEQALLS
PSGKRSLEAA PDTPAKKTKT EGTDGQVKTA VPEAAATGKD YSPPLALREN TIGYLVRLAC
TVYNPSDMIQ RRLVQRVLSL IKKFLEPDVW ADVHIKFTHL ERTLNVKEMN DVLVSSVCSA
LEVLAIDIAH KPYDWFIANM NQLYWLLENS IKSDNVRVHT ALQPVLSHIF SRAVNQTAAT
TTVADSRDDP QHPDVAAFVS LVDSTITDGI ASMNNIYAVL KLLQAASAGR NEQLDPFVPG
IVKMLQKLTK EHITSASVAP PAAPPLPYAQ DSQVNLMVLG LTLLKKRISH LGDQRRWFLT
CLIQLIEKSP DVQLLHAILD MLREWTLTKT ETFPTVKEKA GLLVKMMSLE SRNDTSLTDD
FLDLVIKIYS DPSFARSELT VRLEQAFLLG TRNKNPHIRC QFMRIFDRSI SRSAYTRLNY
ILGVQNWESL SATFWIHQAL DMLFGGAIKV NPPPHILTLK IKSITSVVGQ ETEPSEMDVP
PELNDLVREH QAFLKQLQTS DAANNSAIAS TRQLQYLDDD TAFALWVDLF PMAWAALTSS
EQHDLSKVVI HLLAKEYHSK QAELRPNVVQ ALLTGIAKTM ATGHIKMPPH LVKYLGKTHN
AWHTAMEILL QQQQQQQQSC LADSYNKEDI NSRERTLDAL SDLYAELDEH DMFYGLWRRR
STYSETNVAV SYEQIGCWSP AQTMYENAQI KARSGVLPFT ESEYMLWEDH WIACSQKLQQ
WDILVDLAKH DSNTRLLLNC AWRLSDWAAE RESLEQSVAQ LADTPTPRQK AMEAFLALIK
SQTTDDRLVE FTRVCEEGVQ LSLKKWYALP RIVSQSHLPL LQVFQQYLEL HEASQVFSSL
VTTNVQNLEQ RSNELKSILG TWRERLPNAW DDINMWSDTV AWRRHIFNAI NRAYVPLIPM
LPANTAAAAA AQNGNSFAYR GYHETAWIIN KFAHVARKHK LNDVCLAQLT KIYTLPNIEI
QEAFLKLREQ AKCYYQDPKM LAAGLDVITN TNLNYFSLQQ KAEFYTLKGQ FLARLNQCNE
ANEAFVNAVQ IDLSLPRAWA EWGKYNDARL KENPADLSWA NNAVSCYLQA AGIYKNAKAR
KYLLRVLWLL SLDDANGTVA RAFEGYKGEW PVWYWVTFIP QLLMGLQQRE AKHARAILIR
IAKQFPQALH FQLRTAKEEM MKKANAAKAA TAAAAAATAA SKVSTETTTT TPTTPTTLPT
TTVPSASDTT NAKSETSITE PSLEKEKLAT ENPDVDQKSP KDEAGERPQA EAMEIDSEKS
KDVKDDTTDS KTDEKSEEQN AASDEVKSEP TAESKVPPPI QTGASATGTS ATPTSATSAV
PDTPTTSGPP AHPLDEIMAM LKTGYPLLAL SMETMVDQIQ LKFKPQADED MYRLVVALYN
EGAQVLRCPP HQQLLSRLTN PNDTLQLTSA TIGNIARFAD SLYPGHMKAA FVHDFATTKL
NLEEYVAKLR LWRDKFEAML DARPRKQKLE ACSHYLVEFQ HQKFDDVEIP GQYLLLKDNA
NDFLRIDRFL PQVEVVRSYG NCFRRLTIRG NDGSLHPFVI QNPAARQFRR EERLMQLFRL
LNGVLERKTE TRMRNLQFHL PTIVPLAPNV RMVQDDPSYC TLYDIYEDHC DGSNMHKDDP
LAYFVEKLKA NANKSSTDVS SLKAEMLNLR MEINDEIAKT MVPANILSKY MLRTLGSYTD
YWMHRKQFIA QYATATFMSY IFSVGHRTPH KITISRQTGN IWMTELLPVW NQNNALLGNG
ETVPFRFTPN IQDYMTPVGI EGLFTSCLMA TARSLTEPDL ELDQYLSLFI RDELIAWHTS
SHRSATDAQL CERVQANVNQ IIAKAQFLSC KMDNDKAINS EKPVSQNIID LISQASNPQK
MAQMECTWMP WL
//
