ID A0A0B7NSV4_9FUNG Unreviewed; 946 AA.
AC A0A0B7NSV4;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=PARPA_12349.1 scaffold 44939 {ECO:0000313|EMBL:CEP18049.1};
OS Parasitella parasitica.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Parasitella.
OX NCBI_TaxID=35722 {ECO:0000313|EMBL:CEP18049.1, ECO:0000313|Proteomes:UP000054107};
RN [1] {ECO:0000313|EMBL:CEP18049.1, ECO:0000313|Proteomes:UP000054107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 412.66 {ECO:0000313|EMBL:CEP18049.1,
RC ECO:0000313|Proteomes:UP000054107};
RA Ellenberger Sabrina;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN733737; CEP18049.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B7NSV4; -.
DR STRING; 35722.A0A0B7NSV4; -.
DR OrthoDB; 1332918at2759; -.
DR Proteomes; UP000054107; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000054107}.
FT DOMAIN 453..580
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 660..923
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 120..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 946 AA; 107104 MW; EFB9E8CF95019521 CRC64;
MIENTNAISE EAEDTEEKEY IIETKRVIKQ LESIIFKRNQ NLELCLWRTF DSTIDILFIF
TPKLNTQPKH AAKDHVTTII NASTLLVSVI KLAIIQSLYQ LVKSLLFVFL VNEKQNSSNK
RQSVKLITPP LTPDTMTPDT IAPEKIMPSF QQQQRPQKQQ PSAQHGFDFS HYYQGGMQHA
TRARTDKSSS GKIRSDHANN SSSNNNNMTD TGKRIIRSIS TLRKTTTEAD EDYLTSPRQK
IDQERPWIQS PKDTNVHKGS MRLFFMGGLH KKINKNAATA SHVRDMFDAH NERDHSNPRN
SVQVLRSPNT KNLQIRTKNE LSTSDSGCFT STGSNSPAPI VHTTTSIQKE YAEPVFVQQK
PMKPNRSESD LLQILKPSIS SSSAQWFNSK KKQLLKKSPF LDKEKDKEKL YNVFACDEDD
EILRHAKEKG KEGCILHISE DGQDVLVMEM VSNKLQVLAG TFERLFMKLA DETCQDLDYV
DTYILSHLFF TDSFELLENL MARFHLEALP GEKSYFKKWQ RCIQVKVLNV ISRWIKLQFH
DFKKNPILIT RLEAFLNGDV NRAGFTIEAG MIKEALDRQS SQFLIPKHSF IIQTSQYLTS
YDSNTVANAA ASAGTLGRRP SITPSLLSLA SYATPPASPA SPSHPLYQQL YQQDTFLTIN
PKDIAKYLTL ADFYILKCIT AQDYLAMYYP SQKKQPQQPL VNVNYITMMT ERANKLSKWV
LTEASVHKLH SKQRRAVIRK MIDIAKTCLN WNNFHTSMVI TMGLTQLQEL KGGSCSNSSS
GGSGNNGNGS GTNGGADDGR QLPNRDILTF KSLLKYLNVC NNMSYYRTAF KKSAKAPCIP
FFPIVLKDLT FLIDGNPTKK PDGLINFTKF RILVQSIHTI LNYTAENYDF ASELDHFPFF
PNAPTLSPSS PSYFSLSTSC SMLDQVASIM ETQINQQEPY VTTNTV
//
