ID A0A0C1G8N1_9FLAO Unreviewed; 745 AA.
AC A0A0C1G8N1;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:KIC00256.1};
GN ORFNames=OA93_01195 {ECO:0000313|EMBL:KIC00256.1};
OS Flavobacterium sp. KMS.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1566023 {ECO:0000313|EMBL:KIC00256.1, ECO:0000313|Proteomes:UP000031466};
RN [1] {ECO:0000313|EMBL:KIC00256.1, ECO:0000313|Proteomes:UP000031466}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KMS {ECO:0000313|EMBL:KIC00256.1,
RC ECO:0000313|Proteomes:UP000031466};
RA Smith A.K., Newman J.;
RT "Flavobacterium sp. KMS.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIC00256.1}.
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DR EMBL; JSYP01000001; KIC00256.1; -; Genomic_DNA.
DR RefSeq; WP_039111254.1; NZ_JSYP01000001.1.
DR AlphaFoldDB; A0A0C1G8N1; -.
DR STRING; 1566023.OA93_01195; -.
DR OrthoDB; 9781411at2; -.
DR Proteomes; UP000031466; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 2.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR PROSITE; PS51202; RCK_C; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031466};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 17..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 578..662
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 663..745
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 745 AA; 82884 MW; 49439EA4702F51D7 CRC64;
MSPNETVTHA AQHLEPLISD LGLILMTAGI AVLIFKKLKQ PLVLGYLIAG FLAGNHIEFF
PSVTDNKSVE VWAEIGVIIL LFSLGLEFSF KKLMKVGGTA SITAITQIIT MVAVGYLVGR
WMDWSQMDSI FLGVILSISS TTIILKTFDE LGVKAQKFAG IVIGSLIVQD IIAILMMVLL
STIAVSQQFS GSALLLSVLK LVFFLTAWFV GGIFFIPTLL KKAKHLLTDE MLLIISLALC
LMMVILASNV GFSPALGAFI MGSIIAETTQ AEHIEHLVKP VKDLFGAIFF VSVGMLINPE
MLITHAIPVA ILTLVTIFGQ SISSTIGALL SGQPLKQSVQ TGMSLSQIGE FSFIIATLGM
SLNVTSAFLY PIVVAVSAVT TFTTPFMVKF AGPFSEYLEQ KLPRKWIKNI NRYSLNTQAI
KSVSTWQIVL RSYITQIVIH TIIITAVILL SSKFVAPLVE DTRFGNTIAA LITLIVIAPF
LWALSLRRVA VKEVELLWEE RKYRGPIMMM ILIRIGLGLF YVGFLLNIFF SPLVAFVALV
IAVAAYQFFP KKLNEQYHRI ENHFLKNLND RETTKIDRKY ANLTPWDGHM SIFEIAKESN
LAGKTLEELK IREEMGINIA FIRRGDITIQ IPTKNERLFP GDEICVIGTD AQVSEFTNYL
NKNEIEAPKT TEESEIVLNQ LELSDNEFIK KSISEFRHKT NALVVGIERN GKRILNPESQ
LILEKDDIIW VVGDKKRMKQ FVKKV
//
