ID A0A0C1GMG7_9RHOB Unreviewed; 748 AA.
AC A0A0C1GMG7;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Mechanosensitive ion channel protein MscS {ECO:0000313|EMBL:KIC43446.1};
GN ORFNames=RA27_04565 {ECO:0000313|EMBL:KIC43446.1};
OS Ruegeria sp. ANG-R.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Ruegeria.
OX NCBI_TaxID=1577903 {ECO:0000313|EMBL:KIC43446.1, ECO:0000313|Proteomes:UP000031318};
RN [1] {ECO:0000313|Proteomes:UP000031318}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ANG-R {ECO:0000313|Proteomes:UP000031318};
RX PubMed=25755651; DOI=10.3389/fmicb.2015.00123;
RA Collins A.J., Fullmer M.S., Gogarten J.P., Nyholm S.V.;
RT "Comparative genomics of Roseobacter clade bacteria isolated from the
RT accessory nidamental gland of Euprymna scolopes.";
RL Front. Microbiol. 6:123-123(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIC43446.1}.
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DR EMBL; JWLJ01000001; KIC43446.1; -; Genomic_DNA.
DR RefSeq; WP_039536976.1; NZ_JWLJ01000001.1.
DR AlphaFoldDB; A0A0C1GMG7; -.
DR STRING; 1577903.RA27_04565; -.
DR OrthoDB; 9814206at2; -.
DR Proteomes; UP000031318; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR045276; YbiO_bact.
DR PANTHER; PTHR30460:SF0; MODERATE CONDUCTANCE MECHANOSENSITIVE CHANNEL YBIO; 1.
DR PANTHER; PTHR30460; UNCHARACTERIZED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..748
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002132749"
FT TRANSMEM 124..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 511..548
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 550..614
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 620..707
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
SQ SEQUENCE 748 AA; 82464 MW; B30A37593B598D3F CRC64;
MFHSFRLLLA MVAVVFMAVP LYAQHTSATS TVTIPEDLTP EQVDGLVARM SDDQVRSILL
ERLDAVAKKQ AAQKEGHEDP LTEINEIWTE MVASWTEVLT TVPNIISAQV TAFGNFADKF
AEPGVLTLFG LVLSVLIVGY VAEKLFGILT RRWVKTTEVG EEADLWGAVQ FLFRRFCREI
AGLIVFYVVI RAVGRGLLTP EQITYAAPFV FYLIWIPRLG AAASRFVLAP QKPQFRLVNI
DDHWAKYLHR NLIGLLILIG FTLFVIRFNN LNGVTGSETR IGFWLNAAIH VYIGVIAWTA
REGLSQMMLG TDPDHTKFDE EVARLYPYFA IGVSVVIWFL VEFLVAQRNP AILRVLGSGA
HFTTMFWLLI APALDTLIRG LVRHLQPPMS GEGPLAERAY RSAKRSYIRI GRVVAGVVVV
FMISRAWHLD LRNVASAGIG TDVGGAVIEF LLIIAVGYIL NEIVSLWINR RLAKEQTAAE
ELDEEAGGEG GGAGGSRLAT VLPLLRITAQ ITISVIFGLL ALSALGINIT PLLAGAGVLG
LAIGFGAQKL VADIVGGIFF LIDDAFRVGE YVDVGGTMGT VEKISIRSMQ LRHHRGPVHT
IPYGEIQKLT NFSRDWVIMK LKFTVPFDTD PNKVKKIFKK IGAEMMQDET HKDGFLQPFK
SQGVFDFDDV GMIIRGKFMA KPGKQFTLRK EIFNRVKAEF NANGIDFARR EVRVAIPGLE
EAENLTEEQK AAVGAAAADS INKGEAPA
//
