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Database: UniProt
Entry: A0A0C1KWR0_9PSEU
LinkDB: A0A0C1KWR0_9PSEU
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ID   A0A0C1KWR0_9PSEU        Unreviewed;       672 AA.
AC   A0A0C1KWR0;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   23-MAY-2018, entry version 25.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01020005};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HQ32_03849 {ECO:0000313|EMBL:KID28800.1};
OS   Prauserella sp. Am3.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Prauserella.
OX   NCBI_TaxID=1515610 {ECO:0000313|EMBL:KID28800.1, ECO:0000313|Proteomes:UP000031395};
RN   [1] {ECO:0000313|EMBL:KID28800.1, ECO:0000313|Proteomes:UP000031395}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Am3 {ECO:0000313|EMBL:KID28800.1,
RC   ECO:0000313|Proteomes:UP000031395};
RA   Sarkar I., Sen A., Bose D., Ngom M., Ghazal S.M., Oshone R.T.,
RA   Tisa L.S.;
RT   "Draft genome sequence of Prauserella sp. strain AM3.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00747961}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KID28800.1}.
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DR   EMBL; JTJI01000012; KID28800.1; -; Genomic_DNA.
DR   EnsemblBacteria; KID28800; KID28800; HQ32_03849.
DR   PATRIC; fig|1515610.3.peg.3901; -.
DR   Proteomes; UP000031395; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031395};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00747973};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031395}.
FT   DOMAIN      364    492       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      576    645       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     372    379       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   672 AA;  72045 MW;  1E62C4A4C9FB2316 CRC64;
     MRVTRPIGLL DGTALLAAPS DFAKEAIERA LREPITAALS RRLGREVSLA VKVDAADSAP
     APSGPTTPPQ YGSAGRMEGT LASSADGHGG YSPPASGPGQ HQPPQQPAGT QPAPQHRAPG
     QPGQNPQYPA PQHASAPGQA PYSTSQHPAP HNPASGNAGG PSPSAGQHQS NAQHHSSAQR
     RPAPGRQSGP PNSPAEETMV IPAIRDDMPP PAGTQAATQQ GSPSSDGQAS TGTQGTSTSG
     DASTAASKSG TAKSGTAKSG APQSGGSNGT TXSRRSAGQS RLDALDDSEE EVDEEGEALA
     AVHEIWPTFT GQPTAGQPYT APAQPQTSKT KLNEKYTFDT FVIGASXRFA HAAAVAVAEA
     PSRAYXPLFI WGESGLGKTH LLHAVGHYAQ RLFPGMRVRY VSTEEFTNDF INSLRDDRKV
     AFQRRYRDID ILLVDDIQFL EGKEGTQEEF FHTFNTLHNA NKQIVVSSDR PPKRLETLED
     RLRTRFEWGL ITDIQPPELE TRIAILRKKA AQDRLDVPGD VLEFIAARIE ANIRELEGAL
     IRVTAFASLN QQPVDVGLAX IVLRDLIPDS QAPEISAPTI MGVTAEFFDV TMDDLCGPGK
     TKALATARQI AMYLCRELTD MSLPRIGQTF GGRDHTTVMH ADKKIRKEMA ERRRIYDQVQ
     ELTSRIKQRA RQ
//
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