ID A0A0C1PZV4_9LACO Unreviewed; 278 AA.
AC A0A0C1PZV4;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Oxidoreductase of aldo/keto reductase family, subgroup 1 {ECO:0000313|EMBL:KID41168.1};
GN ORFNames=LfDm3_1314 {ECO:0000313|EMBL:KID41168.1};
OS Fructilactobacillus fructivorans.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Fructilactobacillus.
OX NCBI_TaxID=1614 {ECO:0000313|EMBL:KID41168.1, ECO:0000313|Proteomes:UP000031397};
RN [1] {ECO:0000313|EMBL:KID41168.1, ECO:0000313|Proteomes:UP000031397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DmCS_002 {ECO:0000313|EMBL:KID41168.1,
RC ECO:0000313|Proteomes:UP000031397};
RA Newell P.D., Chaston J.M., Douglas A.E.;
RT "Functional and comparative genomic analyses of the Drosophila gut
RT microbiota identify candidate symbiosis factors.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KID41168.1}.
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DR EMBL; JOJZ01000024; KID41168.1; -; Genomic_DNA.
DR RefSeq; WP_039145135.1; NZ_RIHD01000001.1.
DR AlphaFoldDB; A0A0C1PZV4; -.
DR GeneID; 74913971; -.
DR PATRIC; fig|1614.7.peg.1253; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000031397; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19132; AKR_AKR5D1_E1; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000031397}.
FT DOMAIN 17..260
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT REGION 258..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 50
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 108
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 75
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 278 AA; 31687 MW; 89F4700E0694E1AB CRC64;
MEYEYYTLSN GMQVPKIGFG TYLLKGFEGA MAITSAIHKG YRLIDTAYNY ENEGAVGRGI
ENSNVRRSDL LVTSKLPGRY YDRKSAVDAI QESLYRANLD YFDIYLLHWP NPKEGNYVEA
WQALIDAQQY GLIRTIGVCN FLPDYLDKLV DETGVMPAIN QIELHPYFNQ ADMRHYDDEH
GILTEDWSPL GRASEMLKNP VLVDMAAKYH KNVGQLILRW EIQLGTLPIP KSANPGRQSG
NLDVFDFEIT PEDMKTIASL TKPDGRTHNQ DPATYEEF
//
