ID A0A0C1UMB6_9CYAN Unreviewed; 589 AA.
AC A0A0C1UMB6;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=QQ91_004305 {ECO:0000313|EMBL:NEV66335.1};
OS Lyngbya confervoides BDU141951.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Oscillatoriaceae; Lyngbya.
OX NCBI_TaxID=1574623 {ECO:0000313|EMBL:NEV66335.1, ECO:0000313|Proteomes:UP000031561};
RN [1] {ECO:0000313|EMBL:NEV66335.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BDU141951 {ECO:0000313|EMBL:NEV66335.1};
RA Malar M.C., Sen D., Tripathy S.;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:NEV66335.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BDU141951 {ECO:0000313|EMBL:NEV66335.1};
RX PubMed=25745003;
RA Chandrababunaidu M.M., Sen D., Tripathy S.;
RT "Draft Genome Sequence of Filamentous Marine Cyanobacterium Lyngbya
RT confervoides Strain BDU141951.";
RL Genome Announc. 3:e00066-e00015(2015).
RN [3] {ECO:0000313|EMBL:NEV66335.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BDU141951 {ECO:0000313|EMBL:NEV66335.1};
RA Sarangi A.N., Ghosh S., Mukherjee M., Tripathy S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NEV66335.1}.
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DR EMBL; JTHE02000003; NEV66335.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C1UMB6; -.
DR Proteomes; UP000031561; Unassembled WGS sequence.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF18297; NFACT-R_2; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 457..548
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT COILED 285..312
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
SQ SEQUENCE 589 AA; 66744 MW; FAA8E9F19FCC52B9 CRC64;
MQPVDFTTLM AACAELRQSW LPARCEQVIQ RDATTLAIAL RTLNQRGWLT LSWHPQAARL
HIDSPPPRVP DTFTFSQQLK HQLGGYALVS ITPVAPWERA LDLAFAQRPG DPIEWHLYVE
IMGKYSNVIL VNARNQIVTA AHQVSEQQSS VRPIATGAPY SPPPPIPGPF PKLSEPQERW
QERVGLLPTT LKKALFKAYS GLSSALVRDL TAQADLSPEQ PVETLTPTEW ERLFVQWQGW
LQRLESGQFS PYLFESGYSV LAPIGQPKAD VQTLLRDYYQ EALNRQEFDR LKNQLTQRLK
TLLKKLHQKE TTFAERLDKA DQADDYRQQA DLLMAYNYQW QPGMQSMALA DFETGETVTI
ALDPEKNAIQ NAQAIYKQHQ KLKRSRQAIT PLLQAVRAEI AYLDQVDAAV QRLEQYEAEP
DLIALQEIRD ELIQQTYLED PTYRPGTAAS KDALNVRKFQ TPGNLEVWVG RNNRQNDLLI
SKAATDYDLW FHTQEIPGSH VLLRLDAGQV PTDEDLQFTA DVAAYYSRAQ QADQVPVVFT
QPRYVFKPKG ALPGMVTYTH ETVLWGQPTK LEPQLLENSA SSEPVLTAP
//
