ID A0A0C1Y6X2_9ACTN Unreviewed; 421 AA.
AC A0A0C1Y6X2;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=QR77_25890 {ECO:0000313|EMBL:KIF76382.1};
OS Streptomyces sp. 150FB.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1576605 {ECO:0000313|EMBL:KIF76382.1, ECO:0000313|Proteomes:UP000031584};
RN [1] {ECO:0000313|EMBL:KIF76382.1, ECO:0000313|Proteomes:UP000031584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=150FB {ECO:0000313|EMBL:KIF76382.1,
RC ECO:0000313|Proteomes:UP000031584};
RA Tarkka M.T., Feldhahn L., Kruger D., Buscot F., Wubet T.;
RT "Genome sequence of the mycoparasite antagonist Streptomyces sp. strain FB
RT 150.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIF76382.1}.
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DR EMBL; JTHL01000001; KIF76382.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C1Y6X2; -.
DR STRING; 1576605.QR77_25890; -.
DR Proteomes; UP000031584; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0051920; F:peroxiredoxin activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 1.20.1290.10; AhpD-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029032; AhpD-like.
DR InterPro; IPR003779; CMD-like.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02627; CMD; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF69118; AhpD-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000031584}.
FT DOMAIN 8..163
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..278
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT DOMAIN 324..401
FT /note="Carboxymuconolactone decarboxylase-like"
FT /evidence="ECO:0000259|Pfam:PF02627"
FT REGION 272..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 43288 MW; A6F7C84971433F32 CRC64;
MSAPLTAGVV GLGMIGGGVA VSLARSGRTP VVHDIRSDAA ETLDGVPNPL GSPADVARDS
DVIMVAVVDA DQARAVVTGP EGLLSTARPG ATVVLLSTVA LPVVHELAAA CRDADVRFLD
CGVTPGDKAA DHGMVAIVGG AADDVEHVRP VLADWAKQVV HCGPVGAGMA TKIARNVITY
GSWRTAAEAA ALCSAAGVDP TTLTTVIDAA DPEGSTLLQL LRMRAEGSLT PELHRQIATL
MVKDLDAALS LAGELEVGLP ATGVARNHVA DTLGPGGEER TGDDALTETP ADTPSGRRER
GLAVMEEVYG PAVRESAGAL DTPFTEQTVD YLFGEVWDRP GLSVRDRRLL TLGVAAATGR
SDLIRIQAAG ALNSADFTPG QLDEAVLHLA LYVGWCNATA VHQGVAEALD DHARTSSPKE
K
//
