ID   A0A0C2BGY2_9ACTN        Unreviewed;       774 AA.
AC   A0A0C2BGY2;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=QR77_32750 {ECO:0000313|EMBL:KIF77341.1};
OS   Streptomyces sp. 150FB.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1576605 {ECO:0000313|EMBL:KIF77341.1, ECO:0000313|Proteomes:UP000031584};
RN   [1] {ECO:0000313|EMBL:KIF77341.1, ECO:0000313|Proteomes:UP000031584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=150FB {ECO:0000313|EMBL:KIF77341.1,
RC   ECO:0000313|Proteomes:UP000031584};
RA   Tarkka M.T., Feldhahn L., Kruger D., Buscot F., Wubet T.;
RT   "Genome sequence of the mycoparasite antagonist Streptomyces sp. strain FB
RT   150.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KIF77341.1}.
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DR   EMBL; JTHL01000001; KIF77341.1; -; Genomic_DNA.
DR   RefSeq; WP_040025675.1; NZ_JTHL01000001.1.
DR   AlphaFoldDB; A0A0C2BGY2; -.
DR   STRING; 1576605.QR77_32750; -.
DR   OrthoDB; 3196525at2; -.
DR   Proteomes; UP000031584; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   Gene3D; 3.30.2310.20; RelE-like; 1.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF143011; RelE-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000031584}.
FT   DOMAIN          266..592
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         287..294
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   774 AA;  86406 MW;  74D5D145DC5A30E7 CRC64;
     MTARLSLYEK AEHELYKLDR SVKGKFYDFC HRFRQNPDHP GLDLKPLKGD GRVFRAKIDQ
     SYRALLAKAG VDEQGQERWL VVAVRHRKHV YEELSVAINR VTGEIEFVDL SVVGQSVLQR
     AGVTLTPVDL TPEAELQQPA PPPEVHESVA VEPAAPLLSG ITGEDLRSLG VAAQLIELAL
     AVTESGELDQ LVSGAPLLTK DILYGLAAGM SIDEVRREIT APVEVELADT ERDDLGAALA
     RTTVTTIDDD LRVVLEEGDF RAWKVFLHPA QAKLVDRRYN GPARVSGGPG TGKTIVALHR
     VKHLAQQLPP GHNKPILLTT FTTNLTVDLR ARLSSLLEPD LVARVEITNI DKLAARVLNE
     NSLSGTGKQR IYDSVAIGIL QRLLFELDGK RWEPEFLYEE WEQVILGQSL GNRKAYFDAR
     RAGRGRSVSR PERAQIWKIL EQFTARLDKE NRETWGQAAE RAARFEMERA AKIKARQDRK
     DEVGGKDLIH RDDSSGMRYI AHRYQHVVVD EAQDLRPAHW KMLRAMVAPG PDDMFIAGDT
     YQRIYDQQVT LGTVGVNIRG RSSRLTLSYR TTKEILARAM QVVDGTGNAP SYDDLDDGTD
     TLAGYRSVLR GPVPELAPCE TWDDELTQLA ATLHAWREEL TSGDGNNPRR DPRGNIAVCV
     ADRDSVNQVM YYLATEAGIT VAELTKDGVK GDGEVHVGTM HRFKGLEYQK LAIVGARDGV
     IPRTAVIDRY RESDPQRYAR EERKARSLLF VAATRARDTL RISWHGAPSP YISR
//