ID   A0A0C2CUH1_9BILA        Unreviewed;       684 AA.
AC   A0A0C2CUH1;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Degenerin {ECO:0000313|EMBL:KIH60548.1};
GN   ORFNames=ANCDUO_09200 {ECO:0000313|EMBL:KIH60548.1};
OS   Ancylostoma duodenale.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=51022 {ECO:0000313|EMBL:KIH60548.1, ECO:0000313|Proteomes:UP000054047};
RN   [1] {ECO:0000313|EMBL:KIH60548.1, ECO:0000313|Proteomes:UP000054047}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zhejiang {ECO:0000313|EMBL:KIH60548.1,
RC   ECO:0000313|Proteomes:UP000054047};
RA   Mitreva M.;
RT   "Draft genome of the parsitic nematode Ancylostoma duodenale.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
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DR   EMBL; KN730863; KIH60548.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C2CUH1; -.
DR   Proteomes; UP000054047; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR004726; Deg-1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00867; deg-1; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF267; DEGENERIN MEC-10; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054047};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        70..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   684 AA;  77807 MW;  00EC9DE1388442C5 CRC64;
     MTTYVYGESS NDNDKEIQCD LLTEDGGHEI DPTRLSYKER IRWHLKEFCY KTSSHGIPML
     GQAPNAVYRI VWILLLSGCA FTFVYQAIAV VDKYYRMDKI TDIQLKFDTA PFPAITLCNL
     NPYRDSKIRD EKSINKILSV FKKMMKKAAG AADLEELQHA VEEGKITLKL NRKRREAESK
     GSFEPANSVC NCEDDECEAD ASKIPTESDH MCICAFDRLT HDAWPCHPRE MWLNTTCQHC
     DDHKFCQKRS KTGERHNAPC LCEKGESFCM MYDRVAKILN LWEFFGSSFD YNAEVSDEET
     EALGFGNMTD EVAIVTKAKE NIIFAMSALS EAQRRAARAM SQAKHNLIHK CSFNGKPCDI
     DKDFAIISDP TFGNCFTFNY NRSDFKSSLR AGPMYGLRVM LFVNASDYLP TSEAVGVRLT
     IHDKDEFPFP DTFGYSAPTG YISSFGMRMK KMSRLPAPYG DCIAEGATSN YVYKGYTYST
     EGCYRTCFQQ LIIDRCGCGD PRFPSIGHHQ HCQVFNKEHR ICLEQSTHEL GDIHGSFKCR
     CQQPCNQTIY TMSYSEAIWP SQSLNITLGT CEEEPEICNE QYHRNRNTRI NKGKTRGNNK
     TFRENAAMLE VFYEALNFET LTESEAYGVV KMLADFGGQL GLWSGVSFMT CCEFVCLGCE
     LLYMRILNRT SSNHPASLDF LCSV
//