ID A0A0C2E6P6_9STAP Unreviewed; 839 AA.
AC A0A0C2E6P6;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SN16_05410 {ECO:0000313|EMBL:KIH70997.1};
OS Salinicoccus roseus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae; Salinicoccus.
OX NCBI_TaxID=45670 {ECO:0000313|EMBL:KIH70997.1, ECO:0000313|Proteomes:UP000031546};
RN [1] {ECO:0000313|EMBL:KIH70997.1, ECO:0000313|Proteomes:UP000031546}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W12 {ECO:0000313|EMBL:KIH70997.1,
RC ECO:0000313|Proteomes:UP000031546};
RA Wang H., Yu B.;
RT "Genome sequences of high lactate-tolerant strain Salinicoccus roseus W12
RT with industrial interest.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIH70997.1}.
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DR EMBL; JXII01000004; KIH70997.1; -; Genomic_DNA.
DR RefSeq; WP_040105597.1; NZ_JXII01000004.1.
DR AlphaFoldDB; A0A0C2E6P6; -.
DR STRING; 45670.SN16_05410; -.
DR GeneID; 77844986; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000031546; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000031546}.
FT DOMAIN 673..689
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 599..606
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 839 AA; 96015 MW; 4C208FDB70B59D64 CRC64;
MATVTPMMQQ YLNIKEEHPG VLLFYRLGDF YELFYDDAVT ASKVLEITLT SRDKKKDPIP
MCGVPYHSAK GYIERLIDQG YKVAICEQME DPKKTKGMVK REVVRIITPG TLIDDFGMDD
GRSNYILALD EESELFTAAY SDISTGEIFA FSTGDRDVLK SEIDRIRPRE VVVEADIEDL
MSELYSDPPV TTPFSNETHF PLEYGEGITE GEQKTLDLLV GYIRAHNMKD LKHFRTVEKH
RIKETMQLNY AALSNLELLE SLQTKKTKSS LFWYLNRTET PMGKRKLRKW IERPLLRRTA
IEERHEAVTV LLDHFIERED MRSLLNNVYD IERLVGRLSF GNIDAKDFVQ LRDSLQGLPA
IAEMLERIGL LGTPLFRFFD ILDDVHGLLA DSLDDSPPKT IREGGIFREG YSSRLDEYRY
ISNNGRVWLN DYIERERERT GIKNLKVGFN KVFGYYIEIS KGNAVNFDAE KFDYQRKQTL
TNAERFITPE LKEMESKLLS AQDESVILEY ELFVALREHM EQFIPRLQTT ADIISTLDCL
VSFATVANEY RLVRPEFSED ELSITEGRHP VVEKVIGENT YVPNSLDMDQ DTFIYLITGP
NMSGKSTYMR QVAIISIMAQ MGMYVPAEAA VLPIFDQIFT RIGASDDLAS GKSTFMIEMM
EANDALQNAT ENSLLIFDEI GRGTSTYDGM SLAQAMLEYI HHHIGAKTLF STHYHEMTRL
STELDHLKNV HVKATEYDGK LIFLHKVKPG PVERSYGIHV AKLAELPDEV TTRANDLLRT
FEQDGRVTGS EQLSLPLDDT EAFEAHPVID QLKSLDINQM TPLDAMMKLQ ELKNELEGE
//
