ID A0A0C2FZW4_9ACTN Unreviewed; 701 AA.
AC A0A0C2FZW4;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Choline transporter {ECO:0000313|EMBL:KIH96588.1};
GN ORFNames=LP52_24075 {ECO:0000313|EMBL:KIH96588.1};
OS Streptomonospora alba.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Streptomonospora.
OX NCBI_TaxID=183763 {ECO:0000313|EMBL:KIH96588.1, ECO:0000313|Proteomes:UP000031675};
RN [1] {ECO:0000313|Proteomes:UP000031675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM 90003 {ECO:0000313|Proteomes:UP000031675};
RX PubMed=25601074; DOI=10.1016/j.chembiol.2014.11.017;
RA Metelev M., Tietz J.I., Melby J.O., Blair P.M., Zhu L., Livnat I.,
RA Severinov K., Mitchell D.A.;
RT "Structure, bioactivity, and resistance mechanism of streptomonomicin, an
RT unusual lasso Peptide from an understudied halophilic actinomycete.";
RL Chem. Biol. 22:241-250(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the BCCT transporter (TC 2.A.15) family.
CC {ECO:0000256|ARBA:ARBA00005658}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIH96588.1}.
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DR EMBL; JROO01000056; KIH96588.1; -; Genomic_DNA.
DR RefSeq; WP_040276694.1; NZ_JROO01000056.1.
DR AlphaFoldDB; A0A0C2FZW4; -.
DR STRING; 183763.LP52_24075; -.
DR Proteomes; UP000031675; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071705; P:nitrogen compound transport; IEA:InterPro.
DR InterPro; IPR018093; BCCT_CS.
DR InterPro; IPR000060; BCCT_transptr.
DR NCBIfam; TIGR00842; bcct; 1.
DR PANTHER; PTHR30047:SF7; HIGH-AFFINITY CHOLINE TRANSPORT PROTEIN; 1.
DR PANTHER; PTHR30047; HIGH-AFFINITY CHOLINE TRANSPORT PROTEIN-RELATED; 1.
DR Pfam; PF02028; BCCT; 1.
DR PROSITE; PS01303; BCCT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031675};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 701 AA; 76621 MW; 3D50F6D1BD2ADF5B CRC64;
MSSNGGRGNA PGPGDPATAV KQRPEASRLK PVVFVGASVV ILAISIWAII TPTGADYVIG
TVVGWISRGF GWYYFLVATL YLGFVVFIAL SRYGAVKLGP QHSTPDYGLF AWASMLFAAG
IGIDLLFFSV SGPVTHYLAP PEGDPETIEA ARQAVVWSLF HYGITGWAMY ALMGMALGYF
AFRYRLPLAI RSALYPLIGR RIHGRIGDAV DLAAIIGTVF GISVSLGIGV VQLNYGLNVL
FGIPEGVTAQ VGLIVLAVLV ATVSAVAGVD RGIRRLSEIN VVLAIILMLY VLIAEDPVWL
LNALILNIGD YISRFPEITL NTFAYDQPID WLNAWTLFFW AWWIAWAPFV GLFLARISRG
RTIRQFVAAT LVIPLLYTLT FLSIFGNSAL SIVMGGNTEF GQTAMNTPEH GFYTLLDQYP
GFLFSAGLAT IVGLLLYVTS ADSGALVTGN LSSYLPTPIT DAPAWLRVYW ASVTGLLTLA
MLIVGGVSAL TNATIIMGLP FSFVMILVMW GLSRALRVEG FRSDASRTAL SAPMTARTWR
QRLARAMNFP GKRAGTRFVD EVCRPAFQEV SGELREQGAD ASVVEGVDED TGIPHLELRV
PMGTEEEFSY RVWPIEVPTP AFAIRSLTEH DTYVRFEVYL TEGSQGYDVM GYSKEQLIGN
ILDEYERHLE FLRLHREAVA DSALPDHGPG TAEVYQEDEE R
//
