ID   A0A0C2G406_9ACTN        Unreviewed;       494 AA.
AC   A0A0C2G406;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:KIH97998.1};
GN   ORFNames=LP52_15880 {ECO:0000313|EMBL:KIH97998.1};
OS   Streptomonospora alba.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Nocardiopsaceae; Streptomonospora.
OX   NCBI_TaxID=183763 {ECO:0000313|EMBL:KIH97998.1, ECO:0000313|Proteomes:UP000031675};
RN   [1] {ECO:0000313|Proteomes:UP000031675}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIM 90003 {ECO:0000313|Proteomes:UP000031675};
RX   PubMed=25601074; DOI=10.1016/j.chembiol.2014.11.017;
RA   Metelev M., Tietz J.I., Melby J.O., Blair P.M., Zhu L., Livnat I.,
RA   Severinov K., Mitchell D.A.;
RT   "Structure, bioactivity, and resistance mechanism of streptomonomicin, an
RT   unusual lasso Peptide from an understudied halophilic actinomycete.";
RL   Chem. Biol. 22:241-250(2015).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KIH97998.1}.
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DR   EMBL; JROO01000030; KIH97998.1; -; Genomic_DNA.
DR   RefSeq; WP_040274552.1; NZ_JROO01000030.1.
DR   AlphaFoldDB; A0A0C2G406; -.
DR   STRING; 183763.LP52_15880; -.
DR   OrthoDB; 3802174at2; -.
DR   Proteomes; UP000031675; Unassembled WGS sequence.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR42986; BENZALDEHYDE DEHYDROGENASE YFMT; 1.
DR   PANTHER; PTHR42986:SF1; BENZALDEHYDE DEHYDROGENASE YFMT; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031675}.
FT   DOMAIN          22..480
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   494 AA;  52674 MW;  5A7C0992BCEE33EE CRC64;
     MPAGQLPDPY TVSDRMPLGG AWRPGSSGTT ATDVNPYDDR PVAEFGLADA GDVERSFGAA
     QEAQRSWADT PAPERAELFL RAMAVMDARK DEIVDWLVAE TGGIRERAEF EWGLVRAGMA
     EVVSYPARVS GRILPGTVPG KENRVYRQPL GVVSVISPWN FPMQLSHRSL APALALGNAV
     VLKPAGDTPV TGGTLLARIY EEAGLPPGLL SVVIGKSSEI GDPLVTHETS RLISFTGSTP
     VGESIAAKAP LKRRALELGG NGPLVVLDDA DVERAVEAAL FGSYYHQGQI CMATNRVIVD
     DAVHDDFVDR LTERVRGLRV GDPSDPQTQI GPVVNDSQRD DILDKISRAV DDGAELVLSG
     EPTGPAGRVI PPHLVLGGND VATAAEEVFG PVSTVVRARG EEHALQLADA TEYGLSSAVY
     TGDAERGVRF AQRVEAGMTH VNDTTVNDEP NTAFGGEKAS GIGRFGGEWA IEEFTRDHWV
     SVQHTYRNLP FSSG
//