ID   A0A0C2GBV3_9BILA        Unreviewed;       567 AA.
AC   A0A0C2GBV3;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=ANCDUO_13481 {ECO:0000313|EMBL:KIH56339.1};
OS   Ancylostoma duodenale.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=51022 {ECO:0000313|EMBL:KIH56339.1, ECO:0000313|Proteomes:UP000054047};
RN   [1] {ECO:0000313|EMBL:KIH56339.1, ECO:0000313|Proteomes:UP000054047}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zhejiang {ECO:0000313|EMBL:KIH56339.1,
RC   ECO:0000313|Proteomes:UP000054047};
RA   Mitreva M.;
RT   "Draft genome of the parsitic nematode Ancylostoma duodenale.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KN735895; KIH56339.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C2GBV3; -.
DR   Proteomes; UP000054047; Unassembled WGS sequence.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629:SF58; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 3; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054047};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        93..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        138..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        244..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        274..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        383..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        504..531
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
SQ   SEQUENCE   567 AA;  63953 MW;  7337CF24FC0985EC CRC64;
     MFSVDVTHKC LIAECWVPTV DLPLVKMALR KGTDQAGSPI QAVLNEMETH DMPPTHFKLN
     KFTQGFQNIV DAYGIANYRE VNPAPWSIIS FPFLFAVMFG DSGHGIIMFL AALAFVVFEK
     KLISMKIKDE VCGHLPHLIF NTFFGGRYVV LLMGIFSIYT GLLYNDIYSK SIDIFGSSWK
     NPYPQKLLAE MDEHAMNTSQ TADLTWPPEY SFDSNLGPYP FGVDPIWNVA KNKLNFLNPM
     KMKTSIILGI GQMAFGLILS LCNHIHNRSL VDIFFVFVPQ CFFLGCIFVY LCVMVVLKWI
     FFYVNPTFIF GRLYPGSNCA PSLLIGLINM FMLKGRDPGF VQHVNSPNAT ASVIIGGKNY
     TYDVYDQCYL QQWYPGQVLA EQILLGLAVV SIPIMLLVKP FYVRWLHNRG RPIPGGHGHG
     GGGEEEEVVV WTRRPSRYFS FGDVMVYQAI HTIEFALGCI SHTASYLRLW ALSLAHAQLS
     EVLWDMLLSI GLDMGGWGGS AAVFVLYFFF GVLSISILIL MEGLSAFLHA LRLHWVEFNS
     KFYGGTGVAF EPFYFTRLIR IEEGLEQ
//