ID   A0A0C2HIY6_9BILA        Unreviewed;       286 AA.
AC   A0A0C2HIY6;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Reprolysin family zinc metalloprotease {ECO:0000313|EMBL:KIH69546.1};
GN   ORFNames=ANCDUO_00110 {ECO:0000313|EMBL:KIH69546.1};
OS   Ancylostoma duodenale.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=51022 {ECO:0000313|EMBL:KIH69546.1, ECO:0000313|Proteomes:UP000054047};
RN   [1] {ECO:0000313|EMBL:KIH69546.1, ECO:0000313|Proteomes:UP000054047}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zhejiang {ECO:0000313|EMBL:KIH69546.1,
RC   ECO:0000313|Proteomes:UP000054047};
RA   Mitreva M.;
RT   "Draft genome of the parsitic nematode Ancylostoma duodenale.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KN726141; KIH69546.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C2HIY6; -.
DR   Proteomes; UP000054047; Unassembled WGS sequence.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   PANTHER; PTHR13723:SF278; ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF A, ISOFORM B; 1.
DR   PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR   Pfam; PF13688; Reprolysin_5; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:KIH69546.1};
KW   Metalloprotease {ECO:0000313|EMBL:KIH69546.1};
KW   Protease {ECO:0000313|EMBL:KIH69546.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054047}.
FT   DOMAIN          87..241
FT                   /note="Peptidase M12B"
FT                   /evidence="ECO:0000259|PROSITE:PS50215"
FT   ACT_SITE        238
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ   SEQUENCE   286 AA;  32227 MW;  73A4EE4D12CE942A CRC64;
     MKRGTIIDDS GVHVIHPFPD KHAHRSKRGI DTGNGVHVIF KREAVAPVVD FCGLDNVVTE
     DQLTEDDSAI FEDVFVTGQR LQQMSDLVVE LAVFVDETLW RHFSSKYGGQ AHTKLQDYML
     TLLNNIQIMY YQPSASPPLT FRVIRYEVLT SQPNSIAGTS HNHGNAQMYL DRFCRYQRNL
     GIRDWDHAIM LTGYDIHRGA GSRSISGIAR LDGMCDPWNT CTLAEGLDFT SAFIGTHELG
     HRKPAKTVSS TVEIQAIHTY LTLEKTLHFQ HFDLVMLIAW IAPKAS
//