ID A0A0C2IG39_9PSED Unreviewed; 4108 AA.
AC A0A0C2IG39;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Long-chain-fatty-acid--CoA ligase {ECO:0000313|EMBL:KIH83872.1};
GN ORFNames=UCMB321_2454 {ECO:0000313|EMBL:KIH83872.1};
OS Pseudomonas batumici.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=226910 {ECO:0000313|EMBL:KIH83872.1, ECO:0000313|Proteomes:UP000031535};
RN [1] {ECO:0000313|EMBL:KIH83872.1, ECO:0000313|Proteomes:UP000031535}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCM B-321 {ECO:0000313|EMBL:KIH83872.1,
RC ECO:0000313|Proteomes:UP000031535};
RA Klochko V.V., Zelena L.B., Elena K.A., Reva O.N.;
RT "Complete genome of Pseudomonas batumici UCM B-321 producer of the batumin
RT antibiotic with strong antistaphilococcal and potential anticancer
RT activity.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIH83872.1}.
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DR EMBL; JXDG01000032; KIH83872.1; -; Genomic_DNA.
DR STRING; 226910.UCMB321_2454; -.
DR PATRIC; fig|226910.6.peg.2443; -.
DR Proteomes; UP000031535; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19544; E-C_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF00975; Thioesterase; 2.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:KIH83872.1};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 253..328
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1321..1396
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2383..2457
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3464..3538
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4108 AA; 448364 MW; A5B1A0D0CC69BC0A CRC64;
MIFGGEALDT AMLKPWYARE LNSGTQLVNM YGITETTVHV TYYPLQAEDA QRLGASPIGK
RIPDLQLYVL DARREPVPVG VVGELYVGGA GVARGYLNRA ELSAERFLDN PFSAEANARM
YRTGDLGRWL ADGSLEYFGR NDEQVKIRGF RIELGEIEAR LAAHPGVKES VVLAREDNPG
EKRLVAYVIA QQPETVLEIE SLRGHLQGAL PEYMVPAAYV QLGGVPLTPN GKLDRKALPA
PDLDAVISRD YEAPEGEIEI ALALVWQELL GLSRVGRHDQ FFELGGHSLL AMRLISQIRQ
QLGVEVGLAS LFAHPELTAL AQVIAQAGRS TLPKILPVAR DQAWPLSFAQ QRLWFLAQME
GASAAYHMPA GLSLRGTLDR VALQRALERI VARHEGLRTT FALGDDEQPS QRIAAADAGF
SLQLHDLQGL AAAEEKLQVL AGEEAVQAFD LEQGPLIRGR LIRMAEDHHV LLVTMHHIVS
DGWSMTVLTR ELAALYAAFS QGQDDPLAPL ELQYLDYAVW QRRWLSGELL QQQCSYWQQT
LAEAPALLML PTDRVRPAQQ DYAGAALPVA FDENLTRGLK ALGQRHGTTL YMTVMAAWAA
LLGRLAGQDD VVIGSPVANR MRSEVEGLIG LFVNTLAIRV DLSEQPTAQT LLARVKAATL
GAQAHQDLPF EQVVEVIKPV RSLAHSPVFQ AMLTWQDMGG GDFALGDLQL EGLGASHTLA
KFDISLDLGE AQGRLLGSLE YATALFDEST MVRYLGYFQR LLEAMVADDR QVLEQVPLLD
AAEREHLLVD LNATEVPYPQ DSTIHQLFEE QVRAQPDAIA VAFQAQRLSY AELNRQANRL
AHHLIGLGIG PDDRVAICVE RGVEMMVGLL GVLKAGAAYV PLDPAYPAER LAYMIEDSKP
SALLTQRALQ GRLPVLELPL VLLDDDQRQG LSERDDNPQP ANLGARHLAY VIYTSGSTGN
PKGVMIEHRG LVNYSVDAAR LFGLTPADTV LQQNTLNFDL SVEEIFPALL AGATLAPSQE
IFGSEGSQDH GVRPTFLHMT AAHWHTLAAE WHSQPQVAAQ RLADVRLINV TGDALSAQKL
KLWDEVRPAH TRLINTYGPT EATVSCTAAY VTHDAVAGSE GSGNATIGKP MANTRIYLLD
AHQQPVPYGV AGEIFIGGDG VARGYLNLEQ VNAERFLVDP FSDKPDARMY KTGDLARYMA
DGRIEYLGRN DFQVKVRGFR IELGEIESRL GSCAGVKEAV VIAREDRPGE KRLVAYVVAQ
PEASLDAAGL RAELAPQLAE YMLPGAFVIL DALPLTPNRK LDRKALPAPA DDAFASREHV
APQGATETAL AQIWQNLLNL EQVGRHDHFF DLGGHSLLAM RLISQVRHRL GVELSLADIF
AQPELAALAQ VLAQAAGSSQ PPIVPVSRDQ VLPLSFAQQR LWFLAQLDGG SSAYHIPAGL
RLLGALDRIA LKRALDRIVA RHESLRTTFV QLQGHDAEQR IAPADIGFNL QLHVLAGQAE
AEEELLSIAA EEARESFDLV RGPLVRGRLV RMAEDDHVLL VTLHHIISDG WSAGVLTREL
GVLYEAFRQG AEDPLPALPV QYADYAVWQR NWLSGEVLQQ QGHYWQQALA GAPVLLALPS
DRPRPAQQDY SGHLLGLALD AELTRGLKAL SQRQGTTLFM TVMAAWAAVL SRLSGQDDVV
IGTPAANRLR AEVEDLIGFF VNTLAVRVDV SATLSVETLL QQVKHQTLAA QANQDLPFEQ
VVEVVRPQRS LSHSPIFQAM LSWQNTEEVD LALGDMTLQG VAVTSRTAKF DVLLDMTEVG
DRLLGTLEYA TALFDESTMQ RYLGYLEAML RGMAADERAL IAEIPLLDEE QRGQLLEGFN
ATAVDYPQDL TLHGLFEARV ATGGDAVAVV DEKGSLTYDA LNRQANRIAH RLIGLGIGPD
DRVAICVDRS LEMVAGLMGI LKAGAAYVPL DPDYPIDRLT YMLENCAPTV VLTQEALRAV
LPASNVPVLL LDPEHAEREG FLAQPDSNPL RAEVRPEHLA YVIYTSGSTG QPKGVMNEHR
GVVNRLLWMQ DEYGLDASDS VLQKTPFSFD VSVWEFFWPL FNGARLVMAR PGGHRDPGYL
REVIREQNIT TLHFVPSMLD LFLAHGEAGD SGLLRVMCSG EALPGHLVRR FKQQLPEVGL
FNLYGPTEAA VDVTAWDCAG PLEETPDNTP IGKPVANTRI YLLDANRQPV PLGVAGELYI
GGVQVARGYL NRPELSAERF LDDPFNTGRM YRTGDLGRYL PDGTVEYLGR NDDQVKIRGF
RIELGEIEAR LAAYPGVKES VVLAREDNPG EKRLVAYFSA QQPETVLEIE SLRGHLQGAL
PEYMVPAAYV QLDVLPLTPN GKLDRKALPA PDGAALISRE YEAPQGETET VLAQLWAELL
KVERVGRHDN FFELGGHSLL AVTLIERMRQ VGLSADVRVL FGQPSLSALA AAVGGSTEIV
VPANLIPEHC EHITPDLLPL VSLTQAQIDR VVAAVPGGAA NIQDIYPLAP LQEGILYHHL
AAEQGDPYVQ QALFYLEDRA RLLAFVDAFE GVIGRHDILR TAVLWEGLDE PLQVVLRRAP
MVLEELTFAP EAGDIASQLR GHFDPLHYRL DVRQAPLLRL ACAYDAAQQR WVALLLFHHM
ALDHTALDVV RHEMQAYLLG QQAQLGAAVP YRNYVAQARL GVSQAAHESF FRDMLGDVDE
STLPFGLADV QGDGSAIDQA HLVVEDTLSL RLRQSARQLG VSVASLHHLA WAQVVGALSG
REDVVFGTVL MGRMQGGEGA DRALGMFINT LPLRIEVGAQ GARAGVRATH ARLSALLGHE
HASLALAQRC SGVAAPAPLF SALLNYRHSG GQLDSQAVTA WSGIESLGGD EWTNYPLSLS
IDDLGEAFVL TAQVVAEIGA QRICGYMHAA LDNLVEALER TPEMPLHDLS ILPLAERRQL
LLDFNRTERA YPHGQLIHQL FEAHAAARPQ AIAARQGELS VSYGELDIRA NALAHCLREQ
GVVPGTRVAI LLDRSIDLLA SLLATLKCGA AYLALDRLAP EDRIRFMLED SEATVLLTRS
DLSAPEGTPR LNLDILEPAT LSVNQAPPAL EDNTLAETPA CIIYTSGSTG QPKGVIVSHN
GLARLVQDNG YYDFSPEDRV AFSSNPAFDA SSPEIWGALL NGGQSVIVEH QVLLEPQAFA
ELLGRNEVTV LIISTALFNL YAGLIPAALA RLRMVMCGGE RADPASFRRV REHSSAVRLF
NGYGPTEATT CASRYEVFDV LPGTLGLPIG QPNANVRIYV LNARREPVPV GVVGEMYIGG
AGVALGYLNR PELTAERFSD DPFTEHLGGR LYRTGDLARW LPDGNLEYLA RNDGQVKIRG
FRVELGEIET CLHHCAGVRN AVVVAREDSP GDKYLVAYYT VQPDGEAPES EALRAQLAAD
LPEYMVPGIC MRLDALPLTL NGKVDVRALP APEAERFATH AFEAPHGDLE HRLAQVWAEV
LDLERIGRHD SFFALGGHSL LAVRLVSQLA LAGLPVSLAE LFQHTSVAAL AALLENRTAE
ARSDEQLVPV RTTGSQRPLF LVHEFTGLDL YFPTLGQHID SDIPVYGLPG VALGQTQLQT
MECLATRLLN LMRKVQPQGP YRLAGWSFGG VLAYEIAIQL VGLDEEVEFV GLIDTYLPRL
VDQGRARWNP DSAHKQHLLE HCERFWTGHA EGANPLALLE GLRAELQSFD FEGLLQRCRE
QGVMPPELDV SGTLDLWQYL DREVAHGHAQ AHYTVYANSV PVHLFTASER AHDALAHSGY
LGWDEVLPLS QLHSIKVPGD HRSLMQAPHI EGLGQAINTA LAGLAGRPLP TRVAHQPLLT
IQGGRGDHTP VFCVPGAGDS VTGFIGLTDA FGPHWPIHGL QPRGLDGRTV PYSLVETAAE
AYLQAIDSVH PEGPVHLLGH SFGGWVVFEM ALRLTARGRE VASLTLIDSE SPGGNGVVGK
PYTAMGVLER LIETMQLAAG KSMEVDQAAF AAQDDAGQLR LLHAGMVRAG LLPQRSAADS
MRGPARAFGT ALRTRYQPSS IYTGPVRLVL ADDPVLDAAG NQREQQSMVA GWRRCAPDLS
VWRGPGNHFT ILKAPHVQHL ASWWRSHQ
//
