ID   A0A0C2JLM4_9ACTN        Unreviewed;       244 AA.
AC   A0A0C2JLM4;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=GntR family transcriptional regulator {ECO:0000313|EMBL:KIH99850.1};
GN   ORFNames=LP52_04935 {ECO:0000313|EMBL:KIH99850.1};
OS   Streptomonospora alba.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Nocardiopsaceae; Streptomonospora.
OX   NCBI_TaxID=183763 {ECO:0000313|EMBL:KIH99850.1, ECO:0000313|Proteomes:UP000031675};
RN   [1] {ECO:0000313|Proteomes:UP000031675}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIM 90003 {ECO:0000313|Proteomes:UP000031675};
RX   PubMed=25601074; DOI=10.1016/j.chembiol.2014.11.017;
RA   Metelev M., Tietz J.I., Melby J.O., Blair P.M., Zhu L., Livnat I.,
RA   Severinov K., Mitchell D.A.;
RT   "Structure, bioactivity, and resistance mechanism of streptomonomicin, an
RT   unusual lasso Peptide from an understudied halophilic actinomycete.";
RL   Chem. Biol. 22:241-250(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KIH99850.1}.
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DR   EMBL; JROO01000008; KIH99850.1; -; Genomic_DNA.
DR   RefSeq; WP_040271161.1; NZ_JROO01000008.1.
DR   AlphaFoldDB; A0A0C2JLM4; -.
DR   STRING; 183763.LP52_04935; -.
DR   OrthoDB; 3186208at2; -.
DR   Proteomes; UP000031675; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.20.120.530; GntR ligand-binding domain-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43537:SF5; GALACTONATE OPERON TRANSCRIPTIONAL REPRESSOR; 1.
DR   PANTHER; PTHR43537; TRANSCRIPTIONAL REGULATOR, GNTR FAMILY; 1.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF48008; GntR ligand-binding domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031675};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          12..79
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50949"
SQ   SEQUENCE   244 AA;  26899 MW;  8708EF58464D8479 CRC64;
     MANETLKGLT SETLADRAYR AIRDAVTTGE LRPGQKVTER GLAERLSVSP TPVREAIRRL
     EQDGFLERTG PRTVQVVAFE DVARQDLAEV EVALRGMVAR FGARHASPAQ LDHLDAILDE
     TDDLLILIQR RQEAGEDVSR HLGRLLDAMQ RFNEVVEACA NNPVLVRLLD QTRVFSRPER
     RARLIEEISR NHKFGLDRYG SHRALVRALR AGDSAAAEAL VIEDARGGLG DLLAAPTTPA
     DSVA
//