ID A0A0C2JQT1_9ACTN Unreviewed; 330 AA.
AC A0A0C2JQT1;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Epimerase {ECO:0000313|EMBL:KIH99157.1};
GN ORFNames=LP52_08410 {ECO:0000313|EMBL:KIH99157.1};
OS Streptomonospora alba.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Streptomonospora.
OX NCBI_TaxID=183763 {ECO:0000313|EMBL:KIH99157.1, ECO:0000313|Proteomes:UP000031675};
RN [1] {ECO:0000313|Proteomes:UP000031675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM 90003 {ECO:0000313|Proteomes:UP000031675};
RX PubMed=25601074; DOI=10.1016/j.chembiol.2014.11.017;
RA Metelev M., Tietz J.I., Melby J.O., Blair P.M., Zhu L., Livnat I.,
RA Severinov K., Mitchell D.A.;
RT "Structure, bioactivity, and resistance mechanism of streptomonomicin, an
RT unusual lasso Peptide from an understudied halophilic actinomycete.";
RL Chem. Biol. 22:241-250(2015).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIH99157.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JROO01000014; KIH99157.1; -; Genomic_DNA.
DR RefSeq; WP_040272225.1; NZ_JROO01000014.1.
DR AlphaFoldDB; A0A0C2JQT1; -.
DR STRING; 183763.LP52_08410; -.
DR Proteomes; UP000031675; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0048040; F:UDP-glucuronate decarboxylase activity; IEA:InterPro.
DR GO; GO:0042732; P:D-xylose metabolic process; IEA:InterPro.
DR CDD; cd05230; UGD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR044516; UXS.
DR PANTHER; PTHR43078:SF6; UDP-GLUCURONIC ACID DECARBOXYLASE 1; 1.
DR PANTHER; PTHR43078; UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000031675}.
FT DOMAIN 10..244
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 330 AA; 35397 MW; B8F035B7917F6491 CRC64;
MSQAAIGRAV VTGGAGFVGS HLCGHLLDAG AEVVCIDNFA TGSAENVRHL AGRTGFRTLE
ADVTHPLHVP GRVDTVFHLA SAASPRDYLR LPVETLEAGS RGTRNVLDLA AEHGARTVLA
STSEVYGDPL HHPQHESYWG NVNPVGPRSV YDEAKRYAEA LTMAYHRAHG ADVGIARIFN
SYGPGMRPDD GRAIPTFIRQ ALAGEPITVC GDGMQTRSVC YVDDTVRGLI ALAAADITGP
VNIGSQHELS MHALAELVRA VCGSDSPVVH VGRPQDDPRF RRPDIALAAR ALGWWPLVPM
EEGLRRTVEW FARARTEPED RSAEPTAGRA
//