ID   A0A0C2M6N4_9CYAN        Unreviewed;       701 AA.
AC   A0A0C2M6N4;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:KIJ82816.1};
GN   ORFNames=SD80_14065 {ECO:0000313|EMBL:KIJ82816.1};
OS   Scytonema tolypothrichoides VB-61278.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Scytonemataceae;
OC   Scytonema.
OX   NCBI_TaxID=1233231 {ECO:0000313|EMBL:KIJ82816.1};
RN   [1] {ECO:0000313|EMBL:KIJ82816.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VB-61278 {ECO:0000313|EMBL:KIJ82816.1};
RA   Tripathy S., Das A., Panda A., Malar M.C., Adhikary S.P.;
RT   "Draft genome sequence of Scytonema tolypothrichoides VB-61278.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KIJ82816.1}.
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DR   EMBL; JXCA01000010; KIJ82816.1; -; Genomic_DNA.
DR   STRING; 1233231.SD80_14065; -.
DR   OrthoDB; 9793589at2; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   CDD; cd01988; Na_H_Antiporter_C; 1.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   Gene3D; 3.40.50.12370; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR006016; UspA.
DR   PANTHER; PTHR43562:SF4; NA(+)_H(+) ANTIPORTER NHAS5; 1.
DR   PANTHER; PTHR43562; NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF00582; Usp; 2.
DR   SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          11..374
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   DOMAIN          407..538
FT                   /note="UspA"
FT                   /evidence="ECO:0000259|Pfam:PF00582"
FT   DOMAIN          546..670
FT                   /note="UspA"
FT                   /evidence="ECO:0000259|Pfam:PF00582"
SQ   SEQUENCE   701 AA;  76212 MW;  5C9F3A7EAE5EF158 CRC64;
     MHLEPIVSFA ILLTVILIVP LLFERLKLPG LIGLLIAGVA LGPHGLRLLN TDSETLKLLS
     DIGLVYLMFV AGLEIDMEQF ERTKHRSIGF GTFTFLVPLI VGTIVGRMFG FGWNASVLIG
     SLFASHTLLA YPIISRLGVI NNEAVTVTIG ATIFTDIGSL LVLAVCVAIH EGAFSTFSLV
     KLLLGLVIYS AVILFGFKWL GHEFFRRTGD EQGNQFLFIL LVVFISALGA EVIGVEKIVG
     AFLAGLAVNE VIGSGPVKEK VVFVGNVLFI PIFFVDLGLL IDIPGFIKSI SSVWLTLAIL
     VGLIGSKGAA ALLAKVVYRY NWREMITMWS LSLPQVAATL AATLVGYRAG LLTEGILNGV
     IVLMIVTATL GPLITARSAL GLTITDTTGE PSESMLGRKQ DPTQALTVVV PVHNPETERN
     LIEMAALLIR RESGRVVPLA VTPAHIHMDS PELEKHIQRS KILLSKAVEL GREFGVEVEP
     LARIDQGIVQ GISHASREQD ASLIVMGWSR TTGIRARLFG NVIDSVLWAS HCPVAVTRLL
     DSPSNIRSIL VPIENLSQEA VRVVRFAEIF AEANQAEVTL LHVCARRTSP ARISWMESQL
     DLLVSKDFPQ SRTNIKVVPS DNVVNPILKA SKSCDLLVLR SRRRRLNIGE VAVSDVTTQV
     VQQIQCSVVL LGEPQSYQDN LSKARELVKK SSPVNLTKQE I
//