ID A0A0C2Q4V1_9CYAN Unreviewed; 1195 AA.
AC A0A0C2Q4V1;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=SD81_28365 {ECO:0000313|EMBL:KIJ73415.1};
OS Tolypothrix campylonemoides VB511288.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Tolypothrichaceae;
OC Tolypothrix.
OX NCBI_TaxID=1245935 {ECO:0000313|EMBL:KIJ73415.1};
RN [1] {ECO:0000313|EMBL:KIJ73415.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VB511288 {ECO:0000313|EMBL:KIJ73415.1};
RA Tripathy S., Das S., Gupta A., Malar M.C., Adhikary S.P.;
RT "Draft whole genome shotgun sequence of Tolypothrix campylonemoides
RT VB511288.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIJ73415.1}.
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DR EMBL; JXCB01000012; KIJ73415.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C2Q4V1; -.
DR OrthoDB; 9804325at2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 661..823
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 848..1000
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 121..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1195 AA; 134087 MW; 8B988EBAF083CCE1 CRC64;
MAFSSIVRAL GRSPLTTELL SKLNRQQELL LSGIPRLPKG LIASALAQTE GKNLFVVCAT
LEEAGRWTTQ LEAMGWQTVH FYPTSEASPY EPFDPETEMT WGQMQVLADL VQFGRTRDEG
DKQAKLSSSL PPSLPPSLPP SSPSPKMAIV ATVAALQPHL PPAEAFKPFC ITLKRGMEFD
LDTFSEQITR LGYERVPLVE TEGQWSRRGD IVDVFPVSSE LPVRLDWFGD EIEQLREFDP
ATQRSAALDK IDQLILTPTS FAPIVMAALE DNPQFPVLSE QLNDDSELRT TENSELLEGS
RRFLGLAFDK PASLLDYLPE NTLITVDEPE QCHAHSDRWV ENAEEQWQLL ASREDEEIST
SLPRVHRSFD ECLADTAEFK KLNLSELVEE NTGINLASRR LPVTPHQFAK IAETLRQERD
RKFSVWLISA QPSRSVSLLQ EHDCPAQFIP NPRDYLAIDK QQLNHTPVAL KYSGLAELEG
FILPTFRLVV VTDREFYGQH SLATPSYIRK RRKAASKQVD PNKLRPGDFV VHKNHGVGKF
LKLESLTIND ETREYLVVQY ADGLLRVAAD QVGVLSRLRT ATDKPPELNK MTGKAWENTK
NKVRKAIKKL AVDLLKLYAS RSQQKGNAYP QDTPWQQEME DSFPYQPTTD QLKATQDVKR
DMESDRPMDR LVCGDVGFGK TEVAIRAIFK AVTSGGKQVA LLAPTTILTQ QHYHTLKERF
APYPINVGLL NRFRSAEERR DILKRLATGE LDVVVGTHQL LGKGVTFRDL GLLVVDEEQR
FGVNQKEKIK SLKTLVDVLT LSATPIPRTL YMSLSGIREM SLIATPPPSR RPIQTHLSPT
NPESIRSAIR QELDRGGQVF YVVPRVEGIE EIAAELRQMI PGARIAIAHG QMEESELEST
MLTFSNGEAD ILVCTTIIES GLDIPRVNTI LIEDAHRFGL SQLYQLRGRV GRAGIQAHAW
LFYPKQRTLS DAARQRLRAI QEFAQLGSGY QLAVRDMEIR GVGNLLGAEQ SGQMEAIGFD
LYMEMLEEAI REIRGQEIPK VDDTQIDLNL TAFVPADYIT DLDQKMSAYR AVAAAKSKEE
LSQIAAEWND RYGAIPKPAT QLLRVMELKQ LAKKLGFSRI KPENKQHIVL ETQMEEPGWK
NLAENLPESL RSRFVYSPGK VTVRGLGVMK ADQQLQTLID ALGKMQGAVV EEAIA
//
