ID A0A0C3CUQ6_HEBCY Unreviewed; 2274 AA.
AC A0A0C3CUQ6;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=1-phosphatidylinositol-3-phosphate 5-kinase {ECO:0000256|ARBA:ARBA00012009};
DE EC=2.7.1.150 {ECO:0000256|ARBA:ARBA00012009};
GN ORFNames=M413DRAFT_439251 {ECO:0000313|EMBL:KIM47586.1};
OS Hebeloma cylindrosporum h7.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Hymenogastraceae; Hebeloma.
OX NCBI_TaxID=686832 {ECO:0000313|EMBL:KIM47586.1, ECO:0000313|Proteomes:UP000053424};
RN [1] {ECO:0000313|EMBL:KIM47586.1, ECO:0000313|Proteomes:UP000053424}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=h7 {ECO:0000313|Proteomes:UP000053424};
RG DOE Joint Genome Institute;
RA Kuo A., Gay G., Dore J., Kohler A., Nagy L.G., Floudas D., Copeland A.,
RA Barry K.W., Cichocki N., Veneault-Fourrey C., LaButti K., Lindquist E.A.,
RA Lipzen A., Lundell T., Morin E., Murat C., Sun H., Tunlid A., Henrissat B.,
RA Grigoriev I.V., Hibbett D.S., Martin F., Nordberg H.P., Cantor M.N.,
RA Hua S.X.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053424}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=h7 {ECO:0000313|Proteomes:UP000053424};
RG DOE Joint Genome Institute;
RG Mycorrhizal Genomics Consortium;
RA Kohler A., Kuo A., Nagy L.G., Floudas D., Copeland A., Barry K.W.,
RA Cichocki N., Veneault-Fourrey C., LaButti K., Lindquist E.A., Lipzen A.,
RA Lundell T., Morin E., Murat C., Riley R., Ohm R., Sun H., Tunlid A.,
RA Henrissat B., Grigoriev I.V., Hibbett D.S., Martin F.;
RT "Evolutionary Origins and Diversification of the Mycorrhizal Mutualists.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN831769; KIM47586.1; -; Genomic_DNA.
DR STRING; 686832.A0A0C3CUQ6; -.
DR HOGENOM; CLU_000480_3_0_1; -.
DR OrthoDB; 5481504at2759; -.
DR Proteomes; UP000053424; Unassembled WGS sequence.
DR GO; GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd03334; Fab1_TCP; 1.
DR CDD; cd15725; FYVE_PIKfyve_Fab1; 1.
DR CDD; cd17300; PIPKc_PIKfyve; 1.
DR Gene3D; 3.30.810.10; 2-Layer Sandwich; 1.
DR Gene3D; 3.50.7.10; GroEL; 1.
DR Gene3D; 3.30.800.10; Phosphatidylinositol Phosphate Kinase II Beta; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR InterPro; IPR044769; PIKfyve_PIPKc.
DR InterPro; IPR027483; PInositol-4-P-4/5-kinase_C_sf.
DR InterPro; IPR002498; PInositol-4-P-4/5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45748; 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED; 1.
DR PANTHER; PTHR45748:SF7; 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED; 1.
DR Pfam; PF00118; Cpn60_TCP1; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF01504; PIP5K; 2.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00330; PIPKc; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52029; GroEL apical domain-like; 1.
DR SUPFAM; SSF56104; SAICAR synthase-like; 1.
DR PROSITE; PS51455; PIPK; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00781};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PROSITE-
KW ProRule:PRU00781}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00781};
KW Reference proteome {ECO:0000313|Proteomes:UP000053424};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00781}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 219..279
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1905..2246
FT /note="PIPK"
FT /evidence="ECO:0000259|PROSITE:PS51455"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1387..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1534..1691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1716..1817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1424..1440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1482..1496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1610..1629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1630..1652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1729..1745
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1760
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2274 AA; 254554 MW; CC0EC5BC3A4B72B0 CRC64;
MESPNAVESL SGHSSRSRSS TKLADDVTSL TSFNPFSEED EHDQSSYTLV TSIFSRMKNT
LSAPLSSAVG VSANTSVSNN TNVTTVVGPE ARRPSYTTAQ TGSSTFSSRT NASDRPNPLA
AAPAQAAPPL VSLTPAESEL PTFTVEYDRS PQIHNKVPYS PAFDVGENVP FGTSIPGFPI
QDDARSVKTA TSVHRSGSVS KVIRRLRGEG LSRDYWMDDE NCKECYDCKS IFTTWRRKHH
CRICGQIFCS RCASNIIKGA RFGSEGMVRV CNLCLEKLAK VEEDDDDDRR SVISSVTNFP
AHQFGMDPFT NLAHPQSPFA ASQLFGRTDE PFNLYSVAET RRPLHSQDGS PSRAETSLMR
EGENDVWEPV RDNPAPFRRG LSDEEKDVGQ PPSSFDHDHL APGPEGKSHI QFPTTQPINI
DAPTSSIQFP LGSPEHIGTP RPLNRTKTSS TPYGEFEVAT PFIRSRVQSR LDPTFEAEPG
WRTRRESTAY AQELNLASML HLKIMLRQML TIEGIPNIRE WEETLLRLAL RIAREMTFTA
LPHRQGQDMD VRRYVKIKKI PGGMPKDSEY VTGAVITKNV AHKQMSRLQA NPRVMLVTFP
LEFSRIEGQY MHFGQIVRQE KEYLGNLASR IAALRPHVVL VEKSVSRLAL DALAKHNIAV
ARAVKPSAIQ TIARMTQGDI FSSMDKLALE PRLGHCARYC IQTYDHPLIP GRRKTYMRFE
GCNRDMGCTI ILRGGDIETL KRIKKVTRFL TFIVRNLKLE THLWKDSVIS VPSFNALAIP
SSTSRLLGLD ATAPSLLLGS SSLLPPRFFT SGLGLTSPPK DYDSSKNIGE EDLPNEDAEQ
LRLSRRIDES LGHYTKTFIS VSATLRFPPP YPIQRMKELD NMLLEAKRAW EDEVVRKEER
LQSLHRQEET ITAATVTSDI QTPELQPDMK REDIFAQIEA LPVLSLPSTP LPMDGFPSTS
KLDDDLSYFT LGTLSPNPST PSTAVTPLYR VLAAEEPETM KTATDIYQQS HYTLLKWQHE
EFRRIWEWYL RKNPDDFVVE KYQCIHLREY TIPATNIGQH RPCFAPRLQN IKFYGENDMT
LGQFIEKSVN DTLVQFLDPK AVCTGKGCDQ PLARHCKVFV HNEATLFVAV EQWDGQIIGR
SAYYPSPDLV TTWSACRVCG SATPFIPVSE EMQRYSFAKF LELHFYPADV KLVQGAGCQH
NIYQHHIRYF ASKGMTVRFQ ANPIVLHEVV YPPFRIRVRP ETQLDLKNSD FERLHFRNML
WYTQLIDDLK LISIDAATGD EETDALLLAD INVLITRAEA EREDISRLIN QIYRDSPPTD
TLALNQVHAA RQDKIVAWEM DFDRLPKPRP AQTIVNRNSR SSAFDSMRAI WPSRKYDLAG
AFDNPYIPPS SVSEAEEDPV KSRKTTIADS ASDASENEST EKGKQASDVS PASETKAISN
NEATSDEHVR SDPDSDSTIG ATREDGGSQE IAPLPPQMPD EKEEILSTEE PGQRVSRLPR
RTTQNMSVAE LVKKYQDFLP AQGVHDLAQT AFAPRPVMSE SEQEYPSQVT PRPGIRSKGR
HRLPVRKAST SDFEQGYAAN VAPRYLPHSR KPIPAPSTSR IPAPKGPVFE SHESSRRASP
DKRSFSNQGK EVRFSRPPSP HSTRSTVPGI KQPKNRVISR SKDKIAPRPP SIPNRSTFRR
PPAGAGNKVS NIAKHFERLG RDAEKSKGRY AVIRGKRARP VASARAKVEV LDSVKDAIRD
DSESSDSSSE ADDEDEGNDE EHPAPTAQPD LLEPKPNSLE SDLKIVPPSD SFPATNLDMG
TQEGGATVPL PPPGHISLPS SPFLSSMKSK QETALTPPAS DIELGGPERN SILKALSGFW
PQPARHSIEG DDPMNDPLHI FRDSSMVVRL DEPTSIIALA LDSPTYRDTL AKSRKIAREA
KLTEGSEAFM PDECSIADSS STWNVVNVDS TETVDPTGEL RVPSSKLPLA ITFESNGLTI
SCTVLYPEQF DALRRTYDCE KSMVESLSRC VKWNASGGKS GSAFLKTRDD RFIAKELSKP
ELQTMETFAP AYFDYMSSSV SANRPTLLAK VFGCYKLTFR KTGKDKGPGK SKSTQMNLLV
MENLFYDKRF TKIYDLKGST RNRHVRSTGR ENEVLLDENL VEAAHDKPFY LREHSKRILR
GALYNDSKFL ADINVMDYSL VCGVDSENNE LVVGIVDYIR TYTWDKKLES WVKESAFLGG
AGKGEPTIVT PKQYRQRFLG AMERYFPLVP DRWMKQTDTP EEDSIVLSEL WPDW
//
