ID A0A0C3QH83_9AGAM Unreviewed; 992 AA.
AC A0A0C3QH83;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN ORFNames=M407DRAFT_24793 {ECO:0000313|EMBL:KIO25836.1};
OS Tulasnella calospora MUT 4182.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Tulasnellaceae; Tulasnella.
OX NCBI_TaxID=1051891 {ECO:0000313|EMBL:KIO25836.1, ECO:0000313|Proteomes:UP000054248};
RN [1] {ECO:0000313|EMBL:KIO25836.1, ECO:0000313|Proteomes:UP000054248}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUT 4182 {ECO:0000313|EMBL:KIO25836.1,
RC ECO:0000313|Proteomes:UP000054248};
RG DOE Joint Genome Institute;
RA Kuo A., Girlanda M., Perotto S., Kohler A., Nagy L.G., Floudas D.,
RA Copeland A., Barry K.W., Cichocki N., Veneault-Fourrey C., LaButti K.,
RA Lindquist E.A., Lipzen A., Lundell T., Morin E., Murat C., Sun H.,
RA Tunlid A., Henrissat B., Grigoriev I.V., Hibbett D.S., Martin F.,
RA Nordberg H.P., Cantor M.N., Hua S.X.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054248}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUT 4182 {ECO:0000313|Proteomes:UP000054248};
RG DOE Joint Genome Institute;
RG Mycorrhizal Genomics Consortium;
RA Kohler A., Kuo A., Nagy L.G., Floudas D., Copeland A., Barry K.W.,
RA Cichocki N., Veneault-Fourrey C., LaButti K., Lindquist E.A., Lipzen A.,
RA Lundell T., Morin E., Murat C., Riley R., Ohm R., Sun H., Tunlid A.,
RA Henrissat B., Grigoriev I.V., Hibbett D.S., Martin F.;
RT "Evolutionary Origins and Diversification of the Mycorrhizal Mutualists.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR EMBL; KN823034; KIO25836.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C3QH83; -.
DR STRING; 1051891.A0A0C3QH83; -.
DR HOGENOM; CLU_001718_1_0_1; -.
DR OrthoDB; 211439at2759; -.
DR Proteomes; UP000054248; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR CDD; cd05776; DNA_polB_alpha_exo; 1.
DR Gene3D; 2.40.50.730; -; 1.
DR Gene3D; 3.30.70.2820; -; 1.
DR Gene3D; 6.10.10.100; -; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR024647; DNA_pol_a_cat_su_N.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00592; pol2; 1.
DR PANTHER; PTHR45861; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45861:SF1; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR Pfam; PF12254; DNA_pol_alpha_N; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000054248};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..73
FT /note="DNA polymerase alpha catalytic subunit N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12254"
FT DOMAIN 488..759
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 827..987
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..115
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..263
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..296
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 992
FT /evidence="ECO:0000313|EMBL:KIO25836.1"
SQ SEQUENCE 992 AA; 111114 MW; AD8C2D2D3EB8004A CRC64;
MSSKNKGALA QLKASRAGQK RTDQYKVNRD TRIYDVVDES VYKTVVAGRT LEDDFVEDDG
DHGYADNGEE DWDRGGYDDE RMDVDSEEEE REARRRAKTA KASSSSKSKK PSKPKVKAKA
SSEGEEDDDA PAVSIDAYRK PIAPEKENDF LNSILNDLDT KTAVLPSAPS APKRNGAAHT
TKSVARKRKP SMSDSSDGYG FEDFNNHRES AGFGPSSDVG LQSSPLKPAK KAKLEEVEPK
LGDSSDGDFD TFLTDEDDAA FADLDFNDLQ FEETKPKPTI PPKPEPAKQP PKPPAIKAEP
VDEKPVLSSA SKSKPVMMTD REVKNLDLEV PSWLQVNDIS NVKAKSGDDE GLGPLNSSTN
GATSSSTVNA FEEDGSLRFF WLDYLELDGK LYFVGKVLDR GADGKKRNWV SCCVTVDGIE
RNLFVRPREF RLDKEGLGTD EEVDQDDVYA DFDAIRRSCK VKSWAGKWVR RKYVFDDVEE
GMEAEQDYLK VVYSFGGKYI CSGIEPLIPE EAQSPNIERI YGTKTSAFEL FVLKRKIMGP
CWLNIQNPTI STKGVSWCKL EIEVDNPKTV SPFSESDDNA PRDVPPLTIM SVSLRTIVNH
QTNQREIVSV AVRFWKDMNI DDPTPPEKQE SSAHIVIRCL DKYPAQFEDT ARRQTPVINA
VRNEKALLSS LLTVIKTRDP DVIVGHEFLG VYLDVILMRL KQLKVEPWSC IGRFRRSKWP
TIGRQGSNIR FLQGRLLCDL ASDAAKSMIT STTWSLTEMC GAHLSFNRQE IDPEDTAMYF
DSTVASPDRL LGFVRHCEVD AFLHMALCAK VQMLPLTKQL TSLAGNSWNK TLNGGRAERN
EYILLHEFHR LKYICPDKTW TKKVPAANVK PEVKEEAEDG ENGGAQPVAK PKKDKYKGGL
VFDPKRGLWD TYVLVMDFNS LYPSIIQEFN IDFTTVLKAE IYEGDEEKIP DVPDGGTPQG
VLPRLIATLV NRRRQVKNLM KDPKATESQL MQ
//
