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Database: UniProt
Entry: A0A0C4DFP9_HUMAN
LinkDB: A0A0C4DFP9_HUMAN
Original site: A0A0C4DFP9_HUMAN 
ID   A0A0C4DFP9_HUMAN        Unreviewed;       139 AA.
AC   A0A0C4DFP9;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   11-DEC-2019, entry version 28.
DE   SubName: Full=ATP-sensitive inward rectifier potassium channel 1 {ECO:0000313|Ensembl:ENSP00000316136};
DE   Flags: Fragment;
GN   Name=KCNJ1 {ECO:0000313|Ensembl:ENSP00000316136};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000316136, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000316136, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000316136}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR   EMBL; AP000920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000324003; ENSP00000316136; ENSG00000151704.
DR   EuPathDB; HostDB:ENSG00000151704.15; -.
DR   HGNC; HGNC:6255; KCNJ1.
DR   OpenTargets; ENSG00000151704; -.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00980000198471; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000151704; Expressed in 67 organ(s), highest expression level in adult mammalian kidney.
DR   ExpressionAtlas; A0A0C4DFP9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003268; K_chnl_inward-rec_Kir1.1.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF6; PTHR11767:SF6; 1.
DR   Pfam; PF01007; IRK; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822};
KW   Ion transport {ECO:0000256|RuleBase:RU003822};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822}.
FT   TRANSMEM        64..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          24..139
FT                   /note="IRK"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   NON_TER         139
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000316136"
SQ   SEQUENCE   139 AA;  16321 MW;  A4BD6A5EE834BDB6 CRC64;
     MFKHLRKWVV TRFFGHSRQR ARLVSKDGRC NIEFGNVEAQ SRFIFFVDIW TTVLDLKWRY
     KMTIFITAFL GSWFFFGLLW YAVAYIHKDL PEFHPSANHT PCVENINGLT SAFLFSLETQ
     VTIGYGFRCV TEQCATAIF
//
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