ID A0A0C4DFV1_HUMAN Unreviewed; 740 AA.
AC A0A0C4DFV1;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Regulating synaptic membrane exocytosis 1 {ECO:0000313|Ensembl:ENSP00000359448.4};
DE Flags: Fragment;
GN Name=RIMS1 {ECO:0000313|Ensembl:ENSP00000359448.4};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000359448.4, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000359448.4, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2] {ECO:0007829|PubMed:18220336}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [3] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4] {ECO:0000313|Ensembl:ENSP00000359448.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL034373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL035633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL160405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL390056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL445256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF510957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0C4DFV1; -.
DR SMR; A0A0C4DFV1; -.
DR MassIVE; A0A0C4DFV1; -.
DR PeptideAtlas; A0A0C4DFV1; -.
DR Antibodypedia; 49157; 28 antibodies from 12 providers.
DR Ensembl; ENST00000370420.8; ENSP00000359448.4; ENSG00000079841.20.
DR HGNC; HGNC:17282; RIMS1.
DR VEuPathDB; HostDB:ENSG00000079841; -.
DR GeneTree; ENSGT00940000155134; -.
DR HOGENOM; CLU_001061_0_1_1; -.
DR ChiTaRS; RIMS1; human.
DR Proteomes; UP000005640; Chromosome 6.
DR Bgee; ENSG00000079841; Expressed in cerebellar cortex and 139 other cell types or tissues.
DR ExpressionAtlas; A0A0C4DFV1; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR CDD; cd04028; C2B_RIM1alpha; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039032; Rim-like.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR PANTHER; PTHR12157:SF18; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 1; 1.
DR Pfam; PF00168; C2; 2.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:A0A0C4DFV1,
KW ECO:0007829|PeptideAtlas:A0A0C4DFV1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1..90
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 586..704
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 95..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000359448.4"
SQ SEQUENCE 740 AA; 83353 MW; 09CFB918F8FE8063 CRC64;
RPRNPYVKMY FLPDRSDKSK RRTKTVKKIL EPKWNQTFVY SHVHRRDFRE RMLEITVWDQ
PRVQEEESEF LGEILIELET ALLDDEPHWY KLQTHDESSL PLPQPSPFMP RRHIHGESSS
KKLQRSQRIS DSDISDYEVD DGIGVVPPVG YRSSARESKS TTLTVPEQQR TTHHRSRSVS
PHRGNDQGKP RSRLPNVPLQ RSLDEIHPTR RSRSPTRHHD ASRSPVDHRT RDVDSQYLSE
QDSELLMLPR AKRGRSAECL HTTSELQPFL DRARSASTNC LRPDTSLHSP ERERMHRQRS
PTQSPPADTS FSSRRGRQLP QVPVRSGSIE QASLVVEERT RQMKMKVHRF KQTTGSGSSQ
ELDREQYSKY NIHKDQYRSC DNVSAKSSDS DVSDVSAISR TSSASRLSST SFMSEQSERP
RGRISSFTPK MQGRRMGTSG RSIMKSTSVS GEMYTLEHND GSQSDTAVGT VGAGGKKRRS
SLSAKVVAIV SRRSRSTSQL SQTESGHKKL KSTIQRSTET GMAAEMRKMV RQPSRESTDG
SINSYSSEGN LIFPGVRLGA DSQFSDFLDG LGPAQLVGRQ TLATPAMGDI QIGMEDKKGQ
LEVEVIRARS LTQKPGSKST PAPYVKVYLL ENGACIAKKK TRIARKTLDP LYQQSLVFDE
SPQGKVLQVI VWGDYGRMDH KCFMGVAQIL LEELDLSSMV IGWYKLFPPS SLVDPTLTPL
TRRASQSSLE SSTGPPCIRS
//
