ID A0A0C4DGM4_HUMAN Unreviewed; 226 AA.
AC A0A0C4DGM4;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Hydroxylysine kinase {ECO:0000256|ARBA:ARBA00040505};
DE EC=2.7.1.81 {ECO:0000256|ARBA:ARBA00038873};
GN Name=HYKK {ECO:0000313|Ensembl:ENSP00000457154.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000457154.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000457154.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000457154.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-
CC lysine. {ECO:0000256|ARBA:ARBA00037368}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine +
CC GDP + H(+); Xref=Rhea:RHEA:19049, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:37565, ChEBI:CHEBI:57882, ChEBI:CHEBI:58189,
CC ChEBI:CHEBI:58357; EC=2.7.1.81;
CC Evidence={ECO:0000256|ARBA:ARBA00036820};
CC -!- INTERACTION:
CC A0A0C4DGM4; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-10236738, EBI-10172181;
CC A0A0C4DGM4; Q96IK5: GMCL1; NbExp=5; IntAct=EBI-10236738, EBI-2548508;
CC A0A0C4DGM4; Q14657: LAGE3; NbExp=3; IntAct=EBI-10236738, EBI-1052105;
CC A0A0C4DGM4; Q15654: TRIP6; NbExp=3; IntAct=EBI-10236738, EBI-742327;
CC -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC {ECO:0000256|ARBA:ARBA00006219}.
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DR EMBL; AC027228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0C4DGM4; -.
DR SMR; A0A0C4DGM4; -.
DR IntAct; A0A0C4DGM4; 4.
DR MassIVE; A0A0C4DGM4; -.
DR MaxQB; A0A0C4DGM4; -.
DR PeptideAtlas; A0A0C4DGM4; -.
DR Antibodypedia; 51728; 49 antibodies from 14 providers.
DR Ensembl; ENST00000566332.5; ENSP00000457154.1; ENSG00000188266.14.
DR HGNC; HGNC:34403; HYKK.
DR VEuPathDB; HostDB:ENSG00000188266; -.
DR GeneTree; ENSGT00390000011314; -.
DR HOGENOM; CLU_109187_0_0_1; -.
DR ChiTaRS; HYKK; human.
DR Proteomes; UP000005640; Chromosome 15.
DR Bgee; ENSG00000188266; Expressed in olfactory segment of nasal mucosa and 102 other cell types or tissues.
DR ExpressionAtlas; A0A0C4DGM4; baseline and differential.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR21064:SF1; HYDROXYLYSINE KINASE; 1.
DR PANTHER; PTHR21064; UNCHARACTERIZED; 1.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0C4DGM4,
KW ECO:0007829|ProteomicsDB:A0A0C4DGM4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 37..187
FT /note="Aminoglycoside phosphotransferase"
FT /evidence="ECO:0000259|Pfam:PF01636"
SQ SEQUENCE 226 AA; 25589 MW; EAE7FA53D9AFE7A8 CRC64;
MSSGNYQQSE ALSKPTFSEE QASALVESVF GLKVSKVRPL PSYDDQNFHV YVSKTKDGPT
EYVLKISNTK ASKNPDLIEV QNHIIMFLKA AGFPTASVCH TKGDNTASLV SVDSGSEIKS
YLVRLLTYLP GRPIAELPVS PQLLYEIGKL AAKLDKTLQR FHHPKLSSLH RENFIWNLKN
VPLLEKYLYA LGQNRNREIV EHVIHLFKEE VMTKLSHFRE CEYSPN
//
