ID A0A0C4WGX1_9GAMM Unreviewed; 806 AA.
AC A0A0C4WGX1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN ORFNames=Achr_9560 {ECO:0000313|EMBL:AJE20438.1};
OS Azotobacter chroococcum NCIMB 8003.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Azotobacter.
OX NCBI_TaxID=1328314 {ECO:0000313|EMBL:AJE20438.1, ECO:0000313|Proteomes:UP000068210};
RN [1] {ECO:0000313|EMBL:AJE20438.1, ECO:0000313|Proteomes:UP000068210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCIMB 8003 {ECO:0000313|EMBL:AJE20438.1,
RC ECO:0000313|Proteomes:UP000068210};
RX PubMed=26061173;
RA Robson R.L., Jones R., Robson R.M., Schwartz A., Richardson T.H.;
RT "Azotobacter Genomes: The Genome of Azotobacter chroococcum NCIMB 8003
RT (ATCC 4412).";
RL PLoS ONE 10:E0127997-E0127997(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; CP010415; AJE20438.1; -; Genomic_DNA.
DR RefSeq; WP_039802334.1; NZ_CP010415.1.
DR AlphaFoldDB; A0A0C4WGX1; -.
DR STRING; 1328314.Achr_9560; -.
DR GeneID; 61932262; -.
DR KEGG; acx:Achr_9560; -.
DR HOGENOM; CLU_014785_0_1_6; -.
DR Proteomes; UP000068210; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR10046:SF49; LON PROTEASE HOMOLOG-RELATED; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000068210};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 563..758
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT ACT_SITE 653
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 696
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 806 AA; 88794 MW; 2221AA9559DAACCB CRC64;
MPDSVAAGLR LAPDELTRPF DPAQFAFAST DELEPFRGVL GQERAVEALQ FGVAMPRPGY
NVYVMGEPGT GRFSYVRRYL QTEAKRLDTP PDWVYVNHFE EPREPRSLQL VAGSASEFIA
DINLLIDNLL ATFPAVFETP TYQQKKSAID RGFNQRYDRA LDSIERQALD KGIALYRDSA
NIAFTPMKDG KTLDEGEFAQ LPEAERERFH EDIGYLEERL NEELSSLPQW KRESSNQLRQ
LNEETITLAL QPLLAPLSEK YAESAGVCAY LQAMQVNLLR TVVEQLGDEN VTDAQRRALV
VEQYCPSLVV GHHCQGGAPV VFEPHPTYDN LFGRIEYGTD QGALYTSYRQ LRPGALHRAN
GGFLILEAER LLGEPFVWDA LKRALHSRQL KMESPLAELG RLATVTLTPQ VIPLQVKVVI
VGSRQLYYAL QEVDPDFQEM FRVLVDFDEE IPLADDSLEQ FAQLLKTRTS EEGMAPLSGP
AVARLATYSA RLAEHQGRLS ARIGDLFQLV SEADFVRQLA GEALTDVGHI ERALKAKETR
TGRVSARILD DMLAGIILID TQGAAIGKCN GLTVLEIGDS VFGVPARISA TVYPGGSGIV
DIEREVNLGQ PIHSKGVMIL TGYLGSRYAQ EFPLEISASI ALEQSYGYVD GDSASLGEVC
TLISALSRTP LKQCFAITGS INQFGEVQAV GGVNEKIEGF FRLCEARGLT GEQGVIIPRA
NVTNLMLDER VLQAVRAGRF HVYAVRQVDE ALSLLLGEPA GAADEQGCFP TGSVNARVVE
RLREIAEMGM EEDSGKPKEP QIGVQE
//
