ID A0A0C4WNR4_9GAMM Unreviewed; 1044 AA.
AC A0A0C4WNR4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=Achr_1840 {ECO:0000313|EMBL:AJE19692.1};
OS Azotobacter chroococcum NCIMB 8003.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Azotobacter.
OX NCBI_TaxID=1328314 {ECO:0000313|EMBL:AJE19692.1, ECO:0000313|Proteomes:UP000068210};
RN [1] {ECO:0000313|EMBL:AJE19692.1, ECO:0000313|Proteomes:UP000068210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCIMB 8003 {ECO:0000313|EMBL:AJE19692.1,
RC ECO:0000313|Proteomes:UP000068210};
RX PubMed=26061173;
RA Robson R.L., Jones R., Robson R.M., Schwartz A., Richardson T.H.;
RT "Azotobacter Genomes: The Genome of Azotobacter chroococcum NCIMB 8003
RT (ATCC 4412).";
RL PLoS ONE 10:E0127997-E0127997(2015).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364070}.
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DR EMBL; CP010415; AJE19692.1; -; Genomic_DNA.
DR RefSeq; WP_039800931.1; NZ_CP010415.1.
DR AlphaFoldDB; A0A0C4WNR4; -.
DR STRING; 1328314.Achr_1840; -.
DR KEGG; acx:Achr_1840; -.
DR HOGENOM; CLU_002755_0_1_6; -.
DR Proteomes; UP000068210; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF13; MULTIDRUG EFFLUX PUMP SUBUNIT ACRB-RELATED; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:AJE19692.1};
KW Cell division {ECO:0000313|EMBL:AJE19692.1};
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000068210};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364070}; Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 366..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 437..458
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 470..497
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 538..555
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 873..890
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 897..917
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 923..947
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 968..988
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1000..1026
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
SQ SEQUENCE 1044 AA; 112472 MW; 8687F844E716E8F2 CRC64;
MSRFFIDRPI FAWVIALVIM LAGGLSILAL PINQYPNIAP PAVGISVTYP GASAQTVQDT
VVQVIEQQLN GIDNLRYITS DSNSDGSMTI TVTFEPGTDP DIAQVQVQNK LQLATPLLPQ
EVQQQGIRVT KSVRNFLLIV GFVSEDGSMD RNDLANYIVS NIQDPISRAK GVGDFQVFGS
QYAMRIWLDP ARLNNFQLSP VDVRNAVETQ NVQISSGQFG GLPAVPGQQL SATIIGKTRL
QTAEQFRDIL LKVNGDGSQV RLGDVAEVAL GGENYSITST YNGRPAAGMA IKLATGANAL
ETAQAVRDTL AELEPFFPLG VKVVYPYDTT PVISASIEGV VKTLGEAILL VFLVMYLFLQ
NFRATLIPTL AVPVVLLGTF GVLAAFGFTI NTLTMFAMVL AIGLLVDDAI VVVENVERVM
VEDGLPPREA TRKSMGQIQG ALVGIALVLS AVFVPMAFFG GSTGVIYRQF SITIVAAMAL
SVLVALIFTP ALCATLLKPV AKGEHHQQRG FFGWFNRTFE RSVQGYEQGV RLVLRRKLPY
LLLYLAIVVL MAWLFTRIPT AFLPDEDQGV LYAQVQTPSG SSAERTQLVV DEMRDYLLIE
EGHLVNSVFT VTGFNFAGRG QSSGLAFIAL KPWAGRTGDE DSVFALAQRA QQRFATFRDA
LAFAFAPPAV MELGNASGFN VFLQDRAGAG HEVLGAARDQ LLARAAESPV LSRVRANGLR
DEPQYRLLID DEQARAYGVS LADINSSVSI AWGASYVNDF IDRGRVKKVY LQGKAEARMS
PEDLGKWFVR NAAGAMVPFS AFASGEWTYG PPKLARYNGV SAMEILGEPA PGYSSGDAMA
EVERIVGELP PGIGYAWTGL SYEERLSGSQ APALYALSLL VVFLCLAALY ESWSIPFSVM
LVVPLGVIGA LWFTSLRGLS NDVYFQVGLL TTIGLSAKNA ILIVEFAKEL HAQGMDLSDA
AVEACRMRLR PIVMTSLAFI LGVVPLAISS GAGAGSQHAI GTGVIGGMFT ATVLAIFWVP
LFYVLVSSWF KEDTSTVASG EESS
//
