ID A0A0C4YPN7_9BURK Unreviewed; 744 AA.
AC A0A0C4YPN7;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Tyrosine-protein kinase Wzc {ECO:0000313|EMBL:AJG24450.1};
DE EC=2.7.10.2 {ECO:0000313|EMBL:AJG24450.1};
GN ORFNames=RR42_s2869 {ECO:0000313|EMBL:AJG24450.1};
OS Cupriavidus basilensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=68895 {ECO:0000313|EMBL:AJG24450.1, ECO:0000313|Proteomes:UP000031843};
RN [1] {ECO:0000313|EMBL:AJG24450.1, ECO:0000313|Proteomes:UP000031843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4G11 {ECO:0000313|EMBL:AJG24450.1};
RX PubMed=25977418;
RA Ray J., Waters R.J., Skerker J.M., Kuehl J.V., Price M.N., Huang J.,
RA Chakraborty R., Arkin A.P., Deutschbauer A.;
RT "Complete Genome Sequence of Cupriavidus basilensis 4G11, Isolated from the
RT Oak Ridge Field Research Center Site.";
RL Genome Announc. 3:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; CP010537; AJG24450.1; -; Genomic_DNA.
DR RefSeq; WP_043356605.1; NZ_CP010537.1.
DR AlphaFoldDB; A0A0C4YPN7; -.
DR STRING; 68895.RR42_s2869; -.
DR KEGG; cbw:RR42_s2869; -.
DR OrthoDB; 9808257at2; -.
DR Proteomes; UP000031843; Chromosome secondary.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AJG24450.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000031843};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AJG24450.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..114
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 394..475
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 563..677
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 296..323
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 744 AA; 81066 MW; 853CB6B0093603B6 CRC64;
MATSFDTQYT DVGGPAELRL SDYLVTLVDH WRMIAAVTLL ALVLGTVYAL LQKPVYRADA
MIQVEESKGG NAANANQGSS LQTLSSIFDP NSSTAAEIEL IRSRLVVEEA VRKLHLDIAA
RPRYFPVIGA WLAAYNSGLA PPTELLGLSQ YAWGAESITL SRLDTPQKYY GKVFTLIADS
AHTYTLRDPE GNTVLQGRVG EEAEGTTALG PVHIRVDALV GRGGSRFELV RASTIGTVER
IQRALVVAES ALQSGIIRAS LEGPDPKLTA DIVNTVARQF VQQDIGRRSA EAEHTLAFLD
QQLPALRKEL DLAEERYNSF RNRQGTVNLG EESRLLLQQI VENKTSLARL QTRLAEIRTR
YTDANPAVVA LMAQIETLSA QQSTLRRSVS VLPDTEQTAL RLERDVRVDT ELYTNLLNNA
QQLRIIKAGQ VGNVRVVDFA EPADDPIRPQ RAMLVLISGG VGLVLGALLA FLRKALYGGV
EHPEEIERML GVPVCAVVPR SQTQLRLQRE LRASGSSGLG VLAARAPDDI AVEGVRALRT
TLQYALHTAR DNVVMLTGSR QDAGKSFLSV NLAALVASGR KRVLLIDGDM RRGEVHVHFG
LSQVPGLSDT LMGTDIDSVV IREVLPGLDV LTRGSLPPDP AELLMSDRFH ATLDLFKQRY
DMVIIDTPPV LAVTDATLLG RHAGTTLLVV RHGRHSAAEV TETARRLTSG GVTLHGVLLT
DVPKPPLLLR TGYTEYYGYE GRVK
//
