ID A0A0C4YQ17_9BURK Unreviewed; 292 AA.
AC A0A0C4YQ17;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:AJG24119.1};
GN ORFNames=RR42_s2537 {ECO:0000313|EMBL:AJG24119.1};
OS Cupriavidus basilensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=68895 {ECO:0000313|EMBL:AJG24119.1, ECO:0000313|Proteomes:UP000031843};
RN [1] {ECO:0000313|EMBL:AJG24119.1, ECO:0000313|Proteomes:UP000031843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4G11 {ECO:0000313|EMBL:AJG24119.1};
RX PubMed=25977418;
RA Ray J., Waters R.J., Skerker J.M., Kuehl J.V., Price M.N., Huang J.,
RA Chakraborty R., Arkin A.P., Deutschbauer A.;
RT "Complete Genome Sequence of Cupriavidus basilensis 4G11, Isolated from the
RT Oak Ridge Field Research Center Site.";
RL Genome Announc. 3:0-0(2015).
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DR EMBL; CP010537; AJG24119.1; -; Genomic_DNA.
DR RefSeq; WP_043356149.1; NZ_CP010537.1.
DR AlphaFoldDB; A0A0C4YQ17; -.
DR STRING; 68895.RR42_s2537; -.
DR KEGG; cbw:RR42_s2537; -.
DR OrthoDB; 9777604at2; -.
DR Proteomes; UP000031843; Chromosome secondary.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000031843}.
FT DOMAIN 2..156
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 163..279
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 167
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 292 AA; 29675 MW; 59695B19CE022522 CRC64;
MQIGFIGIGK MGLPMGRHLA AAGHAVEGFD LSPAVLEAAR QAGLKTTGSL AQATAGKDVV
FSSLPHDAAF EAVGAQVAEL AAPGTLYIDT STVSPQASAR VAAVLAQRNI PYLRVTVSGN
NKMAEAAQLT ALVSGPAAAY AVAKPLLAAL GPAQFYLGEA EQARLMKLVV NLMIGLTSGM
LAEALALGAK GGLKWQDMWS VITASAVAAP IVKAKSAQLV ENDYTPTFTV DQMLKDVGLI
LEAGADLRVP LSLTALLGQM LQGAAAQGMA GDDYAAVIKS ARLAAGLPSV NG
//
