ID A0A0C4ZN08_HUMAN Unreviewed; 410 AA.
AC A0A0C4ZN08;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Killer cell immunoglobulin-like receptor 3DL3 {ECO:0000313|Ensembl:ENSP00000492225.1};
DE SubName: Full=Killer cell immunoglobulin-like receptor three domains long cytoplasmic tail 3 {ECO:0000313|EMBL:AJI80993.2};
GN Name=KIR3DL3 {ECO:0000313|EMBL:AJI80993.2,
GN ECO:0000313|Ensembl:ENSP00000492225.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AJI80993.2};
RN [1] {ECO:0000313|Ensembl:ENSP00000492225.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|EMBL:AJI80993.2}
RP NUCLEOTIDE SEQUENCE.
RA Roe D., Vierra-Green C., Pyo C.-W., Eng K., Hall R., Spellman S.,
RA Ranade S., Geraghty D.E., Maiers M.;
RT "Full Haplotype Sequences of the Killer Immunoglobulin-like Receptor (KIR)
RT Region in Several Diverse Diploid Individuals using Single Molecule, Real-
RT Time Sequencing.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSP00000492225.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2022) to UniProtKB.
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DR EMBL; KP420439; AJI80993.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C4ZN08; -.
DR SMR; A0A0C4ZN08; -.
DR MassIVE; A0A0C4ZN08; -.
DR Ensembl; ENST00000639362.1; ENSP00000492225.1; ENSG00000284104.1.
DR HGNC; HGNC:16312; KIR3DL3.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05711; IgC2_D2_LILR_KIR_like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11738:SF113; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 3DL3; 1.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR Pfam; PF00047; ig; 3.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:AJI80993.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..410
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014019455"
FT TRANSMEM 322..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..118
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 40..102
FT /note="Immunoglobulin subtype 2"
FT /evidence="ECO:0000259|SMART:SM00408"
FT DOMAIN 129..218
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 229..325
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
SQ SEQUENCE 410 AA; 44909 MW; D1C4D55788FEFA4C CRC64;
MSLMVVSMAC VGFFLLEGPW PHVGGQDKPF LSAWPGTVVS EGQHVTLQCR SRLGFNEFSL
SKEDGMPVPE LYNRIFRNSF LMGPVTPAHA GTYRCCSSHP HSPTGWSAPS NPVVIMVTGV
HRKPSLLAHP GPLVKSGETV ILQCWSDVRF EHFLLHREGI TEDPLRLVGQ LHDAGSQVNY
SMGPMTPALA GTYRCFGSVT HLPYELSAPS DPLDIVVVGL YGKPSLSAQP GPTVQAGENV
TLSCSSRSLF DIYHLSREAE AGELRLTAVL RVNGTFQANF PLGPVTHGGN YRCFGSFRAL
PHAWSDPSDP LPVSVTGNSR HLHVLIGTSV VIIPFAILLF FLLHRWCANK KNAVVMDQEP
AGNRTVNRED SDEQDPQEVT YAQLNHCVFT QRKITRPSQR PKTPPTDTSV
//
