ID A0A0C5FLK9_9ACTN Unreviewed; 440 AA.
AC A0A0C5FLK9;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Type I polyketide synthase {ECO:0000313|EMBL:AJP00632.1};
GN ORFNames=TU94_02995 {ECO:0000313|EMBL:AJP00632.1};
OS Streptomyces cyaneogriseus subsp. noncyanogenus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=477245 {ECO:0000313|EMBL:AJP00632.1, ECO:0000313|Proteomes:UP000032234};
RN [1] {ECO:0000313|EMBL:AJP00632.1, ECO:0000313|Proteomes:UP000032234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NMWT 1 {ECO:0000313|EMBL:AJP00632.1,
RC ECO:0000313|Proteomes:UP000032234};
RA Wang H., Li C., Xiang W., Wang X.;
RT "Genome sequence of thermotolerant Streptomyces cyaneogriseus subsp.
RT Noncyanogenus NMWT1, the producer of nematocidal antibiotics nemadectin.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP010849; AJP00632.1; -; Genomic_DNA.
DR RefSeq; WP_044378973.1; NZ_CP010849.1.
DR AlphaFoldDB; A0A0C5FLK9; -.
DR STRING; 477245.TU94_02995; -.
DR KEGG; scw:TU94_02995; -.
DR PATRIC; fig|477245.3.peg.665; -.
DR HOGENOM; CLU_049880_0_0_11; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000032234; Chromosome.
DR GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000032234}.
FT DOMAIN 115..413
FT /note="Malonyl-CoA:ACP transacylase (MAT)"
FT /evidence="ECO:0000259|SMART:SM00827"
SQ SEQUENCE 440 AA; 46443 MW; 927459C189CD8006 CRC64;
MTKPATEDVR IGSGAGAVPW VLSGRSAAGL RAQAARLAAR LETDSAASVV DEVTEVGRSL
VAAGTAHEHR AVVLGRDRAD LLLGVRALAE ERAAANVVRG RADRRAGAQV RPVFVFPGQG
TQWAGMAVGL LDTSPLFARE IRACERALSP YVDWSLEDVL RGVPGTPPLD RVDVVQPVLF
SMMVSLARLW HGFGVEPGAA VGHSQGEIAA AHVAGALSLE DAARIVALRS QALTEIRGRG
EMLTVLAPND QVRTMLAAWD GTLSVAAVNG PATMTVSGDL AAMSEFGAAL SAAGMMRWRV
PGVDFAAHSA HVESLRKTLL DLAAGIGPRP GEVPFYSTVT GRRIDTAELD AEYWYRNLRQ
TVRFDEAVRA LLADGHKVFI ECSAQPVLTV GMQDTVEQLG GSAVLMATLR NEDGGTDRFL
AALAEAYVNG VAVDWTPAFA
//
