ID A0A0C5FZJ1_9ACTN Unreviewed; 490 AA.
AC A0A0C5FZJ1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=RNase H type-1 domain-containing protein {ECO:0000259|PROSITE:PS50879};
GN ORFNames=TU94_09945 {ECO:0000313|EMBL:AJP01785.1};
OS Streptomyces cyaneogriseus subsp. noncyanogenus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=477245 {ECO:0000313|EMBL:AJP01785.1, ECO:0000313|Proteomes:UP000032234};
RN [1] {ECO:0000313|EMBL:AJP01785.1, ECO:0000313|Proteomes:UP000032234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NMWT 1 {ECO:0000313|EMBL:AJP01785.1,
RC ECO:0000313|Proteomes:UP000032234};
RA Wang H., Li C., Xiang W., Wang X.;
RT "Genome sequence of thermotolerant Streptomyces cyaneogriseus subsp.
RT Noncyanogenus NMWT1, the producer of nematocidal antibiotics nemadectin.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP010849; AJP01785.1; -; Genomic_DNA.
DR RefSeq; WP_044381222.1; NZ_CP010849.1.
DR AlphaFoldDB; A0A0C5FZJ1; -.
DR STRING; 477245.TU94_09945; -.
DR KEGG; scw:TU94_09945; -.
DR PATRIC; fig|477245.3.peg.2127; -.
DR HOGENOM; CLU_035712_0_0_11; -.
DR OrthoDB; 5296884at2; -.
DR Proteomes; UP000032234; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR CDD; cd09279; RNase_HI_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR48100; BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED; 1.
DR PANTHER; PTHR48100:SF1; PHOSPHOGLYCERATE MUTASE PMU1-RELATED; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000032234}.
FT DOMAIN 1..140
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 132..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 294
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 370
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 346
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 490 AA; 50067 MW; 63BA583E566AA8B1 CRC64;
MREFVVEADG GSRGNPGPAG YGAVVRDAAT GQTLAEAAEY IGVATNNVAE YRGLLAGLRA
ARALDPEASV HVRMDSKLVV EQMSGRWKIK HPGMKPLAAE AAGIFPPGRV TYEWIPRENN
KHADRLANEA MDAGGRGERW RPPEPAAGPD ASAARAAAPE PAGPPGDAAA GAARVRAALA
EGRPATARAG EQSGAGAPPP PPTGTPAESD ARAASGGGRT ATEAPAESGA RPAADSRTDG
PASPAAPRPT VRPSGTTGGS GAARADVRAA RTVAAPGWGP PDMGAPATFV LLRHGETPLT
PQKRFSGSGG SDPSLSAAGR EQAERVAAAL ARRGTVQAIV SSPLARTRET AAIVAARLGL
DVTVEDGLRE TDFGAWEGLT FAEVRERYPD DLNAWLASAD AAPTGGGESF AHTGERIAAT
RDKLVAAHAG RTVLLVTHVT PIKTLVRLAL GAPPESLFRM ELSAASLSAV AYYADGGASV
RLFNDTSHLR
//
