ID A0A0C5GGX9_9ACTN Unreviewed; 1073 AA.
AC A0A0C5GGX9;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=TU94_21550 {ECO:0000313|EMBL:AJP03686.1};
OS Streptomyces cyaneogriseus subsp. noncyanogenus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=477245 {ECO:0000313|EMBL:AJP03686.1, ECO:0000313|Proteomes:UP000032234};
RN [1] {ECO:0000313|EMBL:AJP03686.1, ECO:0000313|Proteomes:UP000032234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NMWT 1 {ECO:0000313|EMBL:AJP03686.1,
RC ECO:0000313|Proteomes:UP000032234};
RA Wang H., Li C., Xiang W., Wang X.;
RT "Genome sequence of thermotolerant Streptomyces cyaneogriseus subsp.
RT Noncyanogenus NMWT1, the producer of nematocidal antibiotics nemadectin.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP010849; AJP03686.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C5GGX9; -.
DR STRING; 477245.TU94_21550; -.
DR KEGG; scw:TU94_21550; -.
DR PATRIC; fig|477245.3.peg.4552; -.
DR HOGENOM; CLU_004900_0_0_11; -.
DR Proteomes; UP000032234; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000032234}.
FT DOMAIN 1..294
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 302..625
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 421..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 13..20
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1073 AA; 115802 MW; 7952BD334433D89A CRC64;
MVDHGSGPLL VLAGPGTGKT TTLVESVAAR IDRGGDPERI LVLTFSRKAA VELRDRMALR
IGAARAPRAT TFHSFGYALV RAHQGGDRPT EPLRLLSGPE QDVTVRGLLA GQADLERLGL
AHVRWPDELR ACLTTRGFAD EVRAVLARSR ELGLGPEALD AFARRIGRPD WRAAAAFLAE
YLDVLDLQGV LDYAELVHRA VLLAGRPEVA ERLAGQYDAV YVDEYQDTDP AQVRLLRALA
GGGRTLVAFG DPDQSIYAFR GADVNGILDF PRTFPRGDGS PAPVQVLRTS RRSGATLLAA
TRRLAQRMPL PRLPADRVRA HREPAPVRDG GRVEVYTYPT SGAELDNIAD ILRRAHLEDG
VPWSEMAVLV RAGSRSIPTL RRALTAAGVP LDVDGDDLPL RHEPAVAPLL TALRAVATAE
AAEASRQRPG TDEPAPGTGG CWLDTETALT LLTSPLAGMD TADLRRLGRA LREEERAAGD
PLPPPSDELL ARALAEPERL AVHDPAYARG AQRLGALLRR ARERLAGGGT AEEALWDLWE
GTPWPGRLER AARRGGAAGR NADRDLDAVC ALFATAARAE ERIGGRGALN FLEEIEAQDI
AADTLTRRAV RPEAVRLMTA HRAKGLQWRL VVVAGVQEGL WPDLRRRGSL LEADRIGRDG
LAEPLTPGAL LAEERRLFYV AATRARERLV VTAVKAPADD GDQPSRFLTE LGVEPKDVTG
RPRRPLSVAA LVAELRATTV DPQASDALRE AAARRLARLA ALADEDGRPL VPSAHPHRWW
GMFEPTESKV PLRDRDKPVV LSGSALEQLA GTCALQWFLG REVKADAPAT AAQGFGNVVH
VLADEVASGH TPADLDVLME RLDSVWNALA FDAPWKSAQE KENARLALER FLKWHVDAHG
ARAGRTAVAS EHDFDVTLRA GDYEVRIRGQ MDRVETDGEG RAYVVDFKTG KQAPSAAEVA
RHPQLAVYQL AVREGAVDAV FDGARPEPGG AELVQLRLGA AKRDGGETLP KVQAQEPLDG
TPGHPGEWIG ELLATAAGKV LDERFTPTAG QHCTHCAFRA SCSARPEGRH VVD
//
