ID A0A0C5WYL2_9GAMM Unreviewed; 1151 AA.
AC A0A0C5WYL2;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=H744_2c1467 {ECO:0000313|EMBL:AJR08145.1};
OS Photobacterium gaetbulicola Gung47.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Photobacterium.
OX NCBI_TaxID=658445 {ECO:0000313|EMBL:AJR08145.1, ECO:0000313|Proteomes:UP000032303};
RN [1] {ECO:0000313|EMBL:AJR08145.1, ECO:0000313|Proteomes:UP000032303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gung47 {ECO:0000313|EMBL:AJR08145.1,
RC ECO:0000313|Proteomes:UP000032303};
RA Kim Y.-O.;
RT "Complete genome sequence of the lipase-producing bacterium Photobacterium
RT gaetbulicola Gung47.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; CP005974; AJR08145.1; -; Genomic_DNA.
DR RefSeq; WP_044622944.1; NZ_CP005974.1.
DR AlphaFoldDB; A0A0C5WYL2; -.
DR STRING; 658445.H744_2c1467; -.
DR KEGG; pgb:H744_2c1467; -.
DR PATRIC; fig|658445.3.peg.3379; -.
DR HOGENOM; CLU_005122_1_3_6; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000032303; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000032303}.
FT DOMAIN 619..780
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 802..955
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1151 AA; 129569 MW; CC188CB7C3024305 CRC64;
MKDQSILSLP LPSKTGDSRF IGNVSGAALA LSVAELAHDH QGPILAVVPD TQTALRLQPE
ISQFSAQEVS VFPDWETLPY DNFSPHQDII SDRLTRLYSL PQQANGVVLV PISTLLQRLT
PRAFIHQHAL MVRNGDKLSL EKLRLQLEAS GYRHVDQVIE HGEYASRGSL IDLFPMGSNQ
PYRIDFFDDE VDSIRQFDPE NQRSTGEIEH IRLLPAHEFP TDEIAIENFR MRWRERFEAR
REPESIYQQV SKRTWPAGIE YWQPLFFEQT ETLFDYLPDN SLLITIGTLE PAVDQFLADA
EYRFEQRRVD PLRPLLEPKE LWLTKDEMFS HFKTLPQVRI RPDNEPEKAG RYNLPLQAIP
KLTINHQLKE PLAELRRFAE SYPGKIVFSV ASEGRREALL DLLARIKLRP VVAPTLTEAL
ATPGKFSLVI GAAEQGFVLE KPEVALICES DLLGERVVQR RRRDEKKSVN ADTIIRNLAE
LKVGQPVVHI DHGIGRYQGL QTLEAGGMKT EYVTLEYQGG AKLYVPVASL HLISRYSGGA
EDTAPIHKLG GEAWVKARKK AAEKVRDVAA ELLDVYAKRE LKPGHKFKLD REAYADFCTG
FPFEETHDQA LAINAVLSDM CQAKAMDRLV CGDVGFGKTE VAMRAAFVAV DNSKQVTVLV
PTTLLAQQHF ENFRDRFANT PVRVEVLSRF KTAKEQKQIL ADMAEGKIDI LIGTHKLLNA
SVDYHDLGLL IVDEEHRFGV RQKEKLKAIR ADVDILTLTA TPIPRTLNMA MSGMRDLSII
ATPPARRLAI KTFVRESDDA LVREAVLREI MRGGQVYFLH NDVDSIEKTA EDLAKLIPEA
RITFAHGQMR ERELEKIMSD FYHQRFNLLV CTTIIETGID VPTANTIVIN RADHLGLAQL
HQLRGRVGRS HHQAYAYLLT PHPKRMTKDA VKRLEAISSL EDLGAGFTLA THDLEIRGAG
ELLGDEQSGQ IQSVGFTLYM EMLEQAVEAL KEGKEPSLDD LLRQQTEVEL RLPALLPEDF
IPDINTRLSL YKRIASANSE KALDELKVEL IDRFGLLPDP TTNLLVLNKI KLKAAGIGVR
KIEAGEKGGF IEFTPNANID PGLLVGLLQS QPQHFRMEGP TKLKVMAPMS DRKDRIKYVD
GLLTKLAENA L
//
