UniProt: A0A0C5XGN4

Database: UniProt
Entry: A0A0C5XGN4_NOCSI

LinkDB:  A0A0C5XGN4_NOCSI 
Original site:  A0A0C5XGN4_NOCSI

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (6)   
   InterPro (4)   
   Pfam (2)   
Literature (1)   
   PubMed (1)   
All databases (15)   

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ID   A0A0C5XGN4_NOCSI        Unreviewed;       484 AA.
AC   A0A0C5XGN4;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Diacylglycerol O-acyltransferase {ECO:0000256|ARBA:ARBA00013244, ECO:0000256|RuleBase:RU361241};
DE            EC=2.3.1.20 {ECO:0000256|ARBA:ARBA00013244, ECO:0000256|RuleBase:RU361241};
GN   ORFNames=KR76_10035 {ECO:0000313|EMBL:AJR18311.1}, NSI01_12540
GN   {ECO:0000313|EMBL:GEB12939.1};
OS   Nocardioides simplex (Arthrobacter simplex).
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Pimelobacter.
OX   NCBI_TaxID=2045 {ECO:0000313|EMBL:AJR18311.1, ECO:0000313|Proteomes:UP000030300};
RN   [1] {ECO:0000313|EMBL:AJR18311.1, ECO:0000313|Proteomes:UP000030300}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM Ac-2033D {ECO:0000313|EMBL:AJR18311.1,
RC   ECO:0000313|Proteomes:UP000030300};
RX   PubMed=25573942;
RA   Shtratnikova V.Y., Schelkunov M.I., Pekov Y.A., Fokina V.V.,
RA   Logacheva M.D., Sokolov S.L., Bragin E.Y., Ashapkin V.V., Donova M.V.;
RT   "Complete Genome Sequence of Steroid-Transforming Nocardioides simplex VKM
RT   Ac-2033D.";
RL   Genome Announc. 3:0-0(2015).
RN   [2] {ECO:0000313|EMBL:GEB12939.1, ECO:0000313|Proteomes:UP000318936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 12069 {ECO:0000313|EMBL:GEB12939.1,
RC   ECO:0000313|Proteomes:UP000318936};
RA   Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT   "Whole genome shotgun sequence of Pimelobacter simplex NBRC 12069.";
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol
CC         + CoA; Xref=Rhea:RHEA:10868, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:58342, ChEBI:CHEBI:64615; EC=2.3.1.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00001039,
CC         ECO:0000256|RuleBase:RU361241};
CC   -!- PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004771, ECO:0000256|RuleBase:RU361241}.
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC   -!- SIMILARITY: Belongs to the long-chain O-acyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009587, ECO:0000256|RuleBase:RU361241}.
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DR   EMBL; CP009896; AJR18311.1; -; Genomic_DNA.
DR   EMBL; BJMC01000008; GEB12939.1; -; Genomic_DNA.
DR   RefSeq; WP_052138437.1; NZ_JAAARG010000300.1.
DR   AlphaFoldDB; A0A0C5XGN4; -.
DR   STRING; 2045.KR76_10035; -.
DR   KEGG; psim:KR76_10035; -.
DR   HOGENOM; CLU_024186_4_2_11; -.
DR   OrthoDB; 9810950at2; -.
DR   UniPathway; UPA00282; -.
DR   Proteomes; UP000030300; Chromosome.
DR   Proteomes; UP000318936; Unassembled WGS sequence.
DR   GO; GO:0004144; F:diacylglycerol O-acyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0019432; P:triglyceride biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR014292; Acyl_transf_WS/DGAT.
DR   InterPro; IPR045034; O-acyltransferase_WSD1-like.
DR   InterPro; IPR009721; O-acyltransferase_WSD1_C.
DR   InterPro; IPR004255; O-acyltransferase_WSD1_N.
DR   NCBIfam; TIGR02946; acyl_WS_DGAT; 1.
DR   PANTHER; PTHR31650:SF1; DIACYGLYCEROL O-ACYLTRANSFERASE TGS4-RELATED; 1.
DR   PANTHER; PTHR31650; O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN; 1.
DR   Pfam; PF06974; WS_DGAT_C; 1.
DR   Pfam; PF03007; WS_DGAT_cat; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU361241};
KW   Glycerol metabolism {ECO:0000256|ARBA:ARBA00022798,
KW   ECO:0000256|RuleBase:RU361241};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516,
KW   ECO:0000256|RuleBase:RU361241};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW   ECO:0000256|RuleBase:RU361241};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030300};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361241}.
FT   DOMAIN          10..276
FT                   /note="O-acyltransferase WSD1-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03007"
FT   DOMAIN          318..468
FT                   /note="O-acyltransferase WSD1 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06974"
SQ   SEQUENCE   484 AA;  52456 MW;  187D9E7BBFEF345D CRC64;
     MNVRPAIERM TGIDAGFLYM ETPSVHMHTL KIAILEADDA LSYDAFVAGM LARLKRLPPL
     RRRVVEVPFG LNHPVWVTQP RIDVAHHIRR HRVGGDGSMR DLEQLVGMIA STPLHRDRPL
     WELHYCAGLE GGRVAIVGKM HHALADGAAA NALLANVTDV RSAAAPEAVQ EEYAATERLP
     GRLDLLRHAW ADAAAQAGTL PALLRRTLRG IVGVLRERRA GARSPVPVLH APRVSFNGAL
     TPLRSFATVT LPLAELKRVR ALHREAGLDV TLNDIVLATT SGALRRWMAD HDERPSSSLL
     AGVPVSADER DAVPRLGGNR VSNLFTTLAT DVDDPTERLR TIARTTADAK RIQARLGASI
     LADWSQFTPP RPFAAAVRAY SRMRAASWHP AAFSAIVSNV PGPREPATVG GARLRDLFSV
     GPLVDGIGLN VTVWSYVDRM NFSLLACPDL LPDVHHLASY FPAALAELDL APPAGAPSLR
     RNPA
//

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