ID A0A0C7MMT7_9SACH Unreviewed; 383 AA.
AC A0A0C7MMT7;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=sphingolipid 4-desaturase {ECO:0000256|ARBA:ARBA00012021};
DE EC=1.14.19.17 {ECO:0000256|ARBA:ARBA00012021};
GN ORFNames=LALA0_S02e08504g {ECO:0000313|EMBL:CEP61180.1};
OS Lachancea lanzarotensis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=1245769 {ECO:0000313|EMBL:CEP61180.1, ECO:0000313|Proteomes:UP000054304};
RN [1] {ECO:0000313|EMBL:CEP61180.1, ECO:0000313|Proteomes:UP000054304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 12615 {ECO:0000313|EMBL:CEP61180.1,
RC ECO:0000313|Proteomes:UP000054304};
RA Neuveglise Cecile;
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family. DEGS
CC subfamily. {ECO:0000256|ARBA:ARBA00006146}.
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DR EMBL; LN736361; CEP61180.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C7MMT7; -.
DR STRING; 1245769.A0A0C7MMT7; -.
DR HOGENOM; CLU_032156_0_1_1; -.
DR OrthoDB; 5485164at2759; -.
DR Proteomes; UP000054304; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042284; F:sphingolipid delta-4 desaturase activity; IEA:UniProtKB-EC.
DR GO; GO:0030148; P:sphingolipid biosynthetic process; IEA:InterPro.
DR CDD; cd03508; Delta4-sphingolipid-FADS-like; 1.
DR InterPro; IPR011388; DES1/DES2.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR013866; Sphingolipid_d4-desaturase_N.
DR PANTHER; PTHR12879; SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2; 1.
DR PANTHER; PTHR12879:SF8; SPHINGOLIPID DELTA(4)-DESATURASE DES1; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR Pfam; PF08557; Lipid_DES; 1.
DR SMART; SM01269; Lipid_DES; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054304};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 218..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..63
FT /note="Sphingolipid delta4-desaturase N-terminal"
FT /evidence="ECO:0000259|SMART:SM01269"
SQ SEQUENCE 383 AA; 44236 MW; 72ADB79BBE2DC47C CRC64;
MPVSHKGLSI GSDTLDAPAA SEELETLHNF YWVSHKEPHA VRRHAILKSH PEVKKLMGPE
PRTKYIVTGV VLLQCAMAFS LRNTSALSWK FWLCAYVVGA TATQNLFLAI HELSHNLAFR
KPWHNKLLSV FTNTPIGIPY AASFAPYHQL HHKFLGDEVY DTDIPTKFEA VVLSSVLGKA
FFATFQIFFY AFRPMFVTSI PLSPLHLINV AYQLAFDYFW ITNFGINSFL YFLISAFLAG
SLHPCSGHFI AEHYLLNMEE ALVGGKLAYK NTPAETETIH STQESEVTRQ DVKFHKDYAL
ETYSYYGILN FFTWNVGLHN EHHDFPFVPW SRLWELNRLC PEYYQDLPKH DSWCMVLWNF
IFTQDVTLYN RVKRVNQHLT KAE
//
