ID A0A0C7MX79_9SACH Unreviewed; 733 AA.
AC A0A0C7MX79;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN ORFNames=LALA0_S12e02366g {ECO:0000313|EMBL:CEP64588.1};
OS Lachancea lanzarotensis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=1245769 {ECO:0000313|EMBL:CEP64588.1, ECO:0000313|Proteomes:UP000054304};
RN [1] {ECO:0000313|EMBL:CEP64588.1, ECO:0000313|Proteomes:UP000054304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 12615 {ECO:0000313|EMBL:CEP64588.1,
RC ECO:0000313|Proteomes:UP000054304};
RA Neuveglise Cecile;
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
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DR EMBL; LN736371; CEP64588.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C7MX79; -.
DR STRING; 1245769.A0A0C7MX79; -.
DR HOGENOM; CLU_012507_1_0_1; -.
DR OrthoDB; 5474157at2759; -.
DR Proteomes; UP000054304; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0044271; P:cellular nitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd04197; eIF-2B_epsilon_N; 1.
DR CDD; cd05787; LbH_eIF2B_epsilon; 1.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035543; eIF-2B_epsilon_N.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000054304}.
FT DOMAIN 553..724
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 521..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 733 AA; 82496 MW; E683496940FAF319 CRC64;
MAGKKGKSSD KAGNNKLKND VVPDERLQAI VLTDSFETRF MPLTAVKPRC LLPLANVPLI
EYTLEFLAKA GASEVYLMCA SHAEQMSEYI EQSKWNQPWS PFRVSTIMSL ESRSVGDAMR
DLDNRGIVTG DFILVSGDLV TNMEFDKALD FHRKRKAEDK DHIVTMCLSR ASQLFRSRCH
EPAAFILDKS NDKCLYYQDI PLENSKLKNA IAIDPELLED VDEFKIRNDL VDCHVDICSP
HVPAIFQENF DYQFLRRDFV KGVLTSDLLK KSIYAFITDD YAARVESWQT YDAISQDFIA
RWCYPMVLNS NLLDDQTYSY ESEHIYKEKD VVLAQSCKIG KCTGIGSGSK IGEGTSIENS
VIGRNCHIKE NIVIKNSFIW DNVTIGSDSV VEHALVASNV SIGSGVVLMD GCVIGFNVSI
DDNMTIPVGT RLSDTYVHKP VSQFLDSEPY SDDEVEESEA NPDNALPALA LVGANGVGYV
YESDDAHDDD EDSSVVFNGT NALTHRFDDL YLSDNSISSM SAKHKKKRRS STNSTAAANG
RDDEYYEEDM DEDEDEEDFA AEAIATVERA MENNHDIDTA LLELNTLRMS INVTYQEVRS
ATVVALLRRV YHFIATQTLG AKDALLKVFG QWGPLFKRQA FDQDEYVDLA NLILEKTVAQ
RFEKPEFIVF TALTFLYDQD ILDEDAVDAW WSQVSQDPKY DQAKVLIAKW IEWLRTADEQ
SSSEEGSEES DSE
//
