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Database: UniProt
Entry: A0A0C7N103_9SACH
LinkDB: A0A0C7N103_9SACH
Original site: A0A0C7N103_9SACH 
ID   A0A0C7N103_9SACH        Unreviewed;       446 AA.
AC   A0A0C7N103;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Phosphomevalonate kinase {ECO:0000256|ARBA:ARBA00012958, ECO:0000256|PIRNR:PIRNR017288};
DE            EC=2.7.4.2 {ECO:0000256|ARBA:ARBA00012958, ECO:0000256|PIRNR:PIRNR017288};
GN   ORFNames=LALA0_S01e05204g {ECO:0000313|EMBL:CEP60197.1};
OS   Lachancea lanzarotensis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=1245769 {ECO:0000313|EMBL:CEP60197.1, ECO:0000313|Proteomes:UP000054304};
RN   [1] {ECO:0000313|EMBL:CEP60197.1, ECO:0000313|Proteomes:UP000054304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 12615 {ECO:0000313|EMBL:CEP60197.1,
RC   ECO:0000313|Proteomes:UP000054304};
RA   Neuveglise Cecile;
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate +
CC         ADP; Xref=Rhea:RHEA:16341, ChEBI:CHEBI:30616, ChEBI:CHEBI:57557,
CC         ChEBI:CHEBI:58146, ChEBI:CHEBI:456216; EC=2.7.4.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00029326};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16342;
CC         Evidence={ECO:0000256|ARBA:ARBA00029326};
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis
CC       via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate:
CC       step 2/3. {ECO:0000256|ARBA:ARBA00005017,
CC       ECO:0000256|PIRNR:PIRNR017288}.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Mevalonate kinase
CC       subfamily. {ECO:0000256|ARBA:ARBA00006495,
CC       ECO:0000256|PIRNR:PIRNR017288}.
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DR   EMBL; LN736360; CEP60197.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C7N103; -.
DR   STRING; 1245769.A0A0C7N103; -.
DR   HOGENOM; CLU_022059_1_0_1; -.
DR   OrthoDB; 991613at2759; -.
DR   UniPathway; UPA00057; UER00099.
DR   Proteomes; UP000054304; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004631; F:phosphomevalonate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.230.10; -; 1.
DR   InterPro; IPR016005; Erg8.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR035102; Phosphomevalonate_kinase.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR01219; Pmev_kin_ERG8; 1.
DR   PANTHER; PTHR31814; -; 1.
DR   PANTHER; PTHR31814:SF2; PHOSPHOMEVALONATE KINASE; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF017288; PMK_GHMP_euk; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|PIRNR:PIRNR017288};
KW   Lipid biosynthesis {ECO:0000256|PIRNR:PIRNR017288};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR017288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054304};
KW   Steroid biosynthesis {ECO:0000256|PIRNR:PIRNR017288};
KW   Steroid metabolism {ECO:0000256|PIRNR:PIRNR017288};
KW   Transferase {ECO:0000256|PIRNR:PIRNR017288}.
FT   DOMAIN          147..211
FT                   /note="GHMP kinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00288"
SQ   SEQUENCE   446 AA;  48854 MW;  58464E11962E3C61 CRC64;
     MQPSRAFSAP GKALLVGGHL VLDPLYESYV VALSSRMHCV VSKLPSNGID HFSVTIKSAQ
     FDSDEWNYKI LRGSSYEVLE VDGKKNPFAK KAVEVLVNYC QPDPQTTENV VLEVFSDSAY
     HSTGTSTLKK NEYNQFRFHD STITKVPKTG LGSSAGLVSV LVTSLLSVYQ GNLDVNSPND
     QKTIHNLAQV AHCQAQGKVG SGFDVAAAVF GSIIYQRFDA KLIENLPTEQ PAEYAQAIRI
     LIDLTDWNFT HDKVTLPPGI RVIMGDVSSG SETTKLVAKV KAWYQQNLPR SLTVFHCINQ
     GNLKFIEGIE KLTTLSRESP AVYQELLEKL DSGHDANASV EITQIRHAIT QVRENFQLIT
     RESGADIEPS SQTSLLERCL KLNGVITGVV PGAGGYDAIA LLVTETADIP SQTSGNADFS
     TVTWLDLHQE NMGIVEEKPS HYLNLQ
//
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